LP-935001
LP-935001 is a Notum carboxylesterase inhibitor with an IC50 of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1875037-24-3
- Fòrmula: C13H8ClFO2S
- Peso molecular:282.72
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
LP-935001 potently inhibits human Notum carboxylesterase activity in a cell-free biochemical assay with an IC50 of 0.4 nM[1].
LP-935001 restores Wnt/β-catenin signaling in a cell-based reporter assay in the presence of Notum with an EC50 of 12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1875037-24-3
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Peso molecular 282.72
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Fòrmula C13H8ClFO2S
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SMILES
O=C(C1=CC2=C(C3=C(CC2)C(Cl)=CC(F)=C3)S1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LP-935001 Related Classifications
HY-182632 Related Classifications
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