2. Gene
  3. FGFR1 - fibroblast growth factor receptor 1 Gene

FGFR1 - fibroblast growth factor receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)

Also known as FLG-1

Gene ID: 100856477 | Gene type: protein coding

About FGFR1

Primary_assembly 16: 28,927,382-28,977,436 forward strand.ROS_Cfam_1.0:CM025115.1

This gene has 6 transcripts (splice variants), 293 orthologues and 54 paralogues.

FGFR1 Products(9)

mRNA Protein Name
XM_038689853.1 XP_038545781.1 fibroblast growth factor receptor 1 isoform X4
XM_038689854.1 XP_038545782.1 fibroblast growth factor receptor 1 isoform X1
XM_038689857.1 XP_038545785.1 fibroblast growth factor receptor 1 isoform X6
XM_038689850.1 XP_038545778.1 fibroblast growth factor receptor 1 isoform X1
XM_038689856.1 XP_038545784.1 fibroblast growth factor receptor 1 isoform X5
XM_038689855.1 XP_038545783.1 fibroblast growth factor receptor 1 isoform X2
XM_038689852.1 XP_038545780.1 fibroblast growth factor receptor 1 isoform X3
XM_038689859.1 XP_038545787.1 fibroblast growth factor receptor 1 isoform X7
XM_038689851.1 XP_038545779.1 fibroblast growth factor receptor 1 isoform X1

FGFR1 Protein Structure

IgI_1_FGFR

IgI_1_FGFR: cd04973 (24 - 117)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (24 - 27)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (39 - 45)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (48 - 58)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (62 - 67)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (70 - 72)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (77 - 81)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (84 - 89)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (95 - 104)

IgI_1_FGFR

IgI_1_FGFR: cd04973 (107 - 117)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (152 - 246)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (152 - 155)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (163 - 168)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (172 - 180)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (186 - 191)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (194 - 196)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (205 - 208)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (212 - 217)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (226 - 233)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (236 - 246)

Ig

Ig: cl11960 (254 - 358)

Ig

Ig: cd00096 (272 - 276)

Ig

Ig: cd00096 (285 - 289)

Ig

Ig: cd00096 (323 - 327)

Ig

Ig: cd00096 (337 - 342)

Ig

Ig: cd00096 (350 - 353)

PTKc_FGFR1

PTKc_FGFR1: cd05098 (463 - 764)

  • 0
  • 200
  • 400
  • 600
  • 822 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor receptor 1

fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)

Related Agents

Approval
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10981 Lenvatinib Inhibitor 99.75% Yes
HY-50904 Nintedanib Inhibitor 99.94% Yes
HY-18708 Erdafitinib 99.66% Unkown
HY-12047 Ponatinib 99.67% Yes
HY-13311 Infigratinib 99.82% Yes
HY-10208 Pazopanib 99.91% Yes
HY-109099 Pemigatinib Inhibitor 99.84% Yes
HY-N0060 Ferulic acid Inhibitor 99.97% Yes
HY-100818 Futibatinib Inhibitor 99.90% Unkown
HY-11106 Nintedanib esylate Inhibitor 99.96% Yes
HY-10981A Lenvatinib mesylate Inhibitor 99.91% Yes
HY-12297 Sulfatinib Inhibitor 99.52% Unkown
HY-108766 Ponatinib hydrochloride 99.76% Yes
HY-12009 Pazopanib Hydrochloride 99.99% Yes
HY-13311A Infigratinib phosphate Inhibitor 99.59% Yes
HY-N0060A Ferulic acid sodium Inhibitor 99.88% Yes
Clinical Phase
Bioactive Molecules (30)
Cat. No. Product Name Effect
Purity Phase
HY-101296 PD-166866 99.75% Phase 4
HY-13330 Fexagratinib Inhibitor 99.92% Phase 3
HY-50905 Dovitinib Inhibitor 99.88% Phase 3
HY-19981 Derazantinib Inhibitor 99.41% Phase 3
HY-10517 Orantinib 99.29% Phase 3
HY-100019 Rogaratinib Inhibitor 99.86% Phase 3
HY-145601 Tinengotinib Inhibitor 99.57% Phase 3
HY-15391 Lucitanib Inhibitor 98.94% Phase 3
HY-10337 Brivanib 99.92% Phase 3
HY-10207 Dovitinib lactate Inhibitor 99.75% Phase 3
HY-10336 Brivanib (alaninate) 99.45% Phase 3
HY-B0062 Dovitinib lactate hydrate Inhibitor / Phase 3
HY-16135 CEP-11981 Inhibitor 99.88% Phase 2
HY-13304 LY2874455 Inhibitor 99.14% Phase 2
HY-10987A ENMD-2076 99.99% Phase 2
HY-19957 Zoligratinib Inhibitor 99.76% Phase 2
HY-10186 TG 100801 Inhibitor 98.61% Phase 2
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
HY-10987 ENMD-2076 Tartrate 99.66% Phase 2
HY-19981B Derazantinib dihydrochloride Inhibitor / Phase 2
HY-101466A E7090 succinate Inhibitor 99.17% Phase 2
HY-16135A CEP-11981 tosylate Inhibitor / Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-12624 Narazaciclib Inhibitor 98.66% Phase 1
HY-100491 H3B-6527 Inhibitor 98.0% Phase 1
HY-19983 ASP5878 Inhibitor 99.69% Phase 1
HY-101768 PRN1371 Inhibitor 99.78% Phase 1
HY-156632 Resigratinib Inhibitor 99.53% Phase 1
HY-100315 XL 999 Inhibitor 99.01% Phase 1
HY-131908 CPL304110 Inhibitor 99.85% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99614 Fazpilodemab Agonist 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (141)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10321 PD173074 99.86% Unkown
HY-10407 SU 5402 Inhibitor 99.78% Unkown
HY-P5321 bFGF (119-126) Inhibitor 99.93% Unkown
HY-147250 Lirafugratinib Inhibitor 99.67% Unkown
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-108628 SU16f Inhibitor 99.36% Unkown
HY-18602 FIIN-2 Inhibitor 99.32% Unkown
HY-N5112A β,β-Dimethylacrylalkannin 99.36% Unkown
HY-15813 FIIN-1 Inhibitor 99.04% Unkown
HY-101466 E7090 Inhibitor 98.11% Unkown
HY-136605 DGY-06-116 Inhibitor 98.62% Unkown
HY-15590 AZ-23 Inhibitor 98.92% Unkown
HY-145231 FGFR2-IN-2 Inhibitor 98.25% Unkown
HY-100434 PD-161570 Inhibitor 99.82% Unkown
HY-102071 KIN59 Inhibitor 99.0% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-10185 TG 100572 Hydrochloride Inhibitor 98.76% Unkown
HY-N7715 Ferulic acid acyl-β-D-glucoside 99.33% Unkown
HY-148779 FGFR3-IN-5 Inhibitor 99.16% Unkown
HY-137967 Genistein 7-β-D-Glucuronide 98.76% Unkown
HY-114311 FGFR1/DDR2 inhibitor 1 Inhibitor 98.26% Unkown
HY-156019 FGFR1 inhibitor-10 Inhibitor 98.31% Unkown
HY-118203 SU4984 Inhibitor 99.70% Unkown
HY-W007587 9-Bromononanoic acid 98.0% Unkown
HY-147250A Lirafugratinib hydrochloride Inhibitor 98.96% Unkown
HY-16025 EOC317 Inhibitor 98.01% Unkown
HY-133980A O-Demethyl Lenvatinib hydrochloride 97.08% Unkown
HY-163705 BR-cpd7 Degrader 98.01% Unkown
HY-50904S2 Nintedanib-d8 Inhibitor 99.90% Unkown
HY-60218 1-Boc-3-(hydroxymethyl)pyrrolidine 97.86% Unkown
HY-18603 FIIN-3 Inhibitor 99.01% Unkown
HY-175743 TYRA-200 Inhibitor 98.06% Unkown
HY-10981S Lenvatinib-d4 Inhibitor 99.59% Unkown
HY-176862A TCB-32 hydrochloride / Unkown
HY-RS04911 FGFR1 Human Pre-designed siRNA Set A / Unkown
HY-10517A (Z)-Orantinib Inhibitor 99.44% Unkown
HY-108933 JK-P3 Inhibitor 99.75% Unkown
HY-15599 SSR128129E Inhibitor 99.18% Unkown
HY-162153 CYY292 Inhibitor 99.19% Unkown
HY-15391A Lucitanib dihydrochloride Inhibitor 98.12% Unkown
HY-12965 S49076 Inhibitor 99.44% Unkown
HY-13737 R1530 99.06% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-164853 Kanglexin Inhibitor 99.65% Unkown
HY-165298 DGY-09-192 99.50% Unkown
HY-50904S1 Nintedanib-13C,d3 Inhibitor 99.84% Unkown
HY-P3281 FGL peptide Activator 99.69% Unkown
HY-RS04912 Fgfr1 Mouse Pre-designed siRNA Set A / Unkown
HY-19981A Derazantinib Racemate Inhibitor 99.38% Unkown
HY-10208S Pazopanib-d6 98.0% Unkown
HY-12009S Pazopanib-13C,d3 hydrochloride 97.51% Unkown
HY-12047S Ponatinib-d8 99.16% Unkown
HY-13311S Infigratinib-d3 Inhibitor 98.90% Unkown
HY-133980 O-Demethyl Lenvatinib / Unkown
HY-145043 FGFR-IN-1 Inhibitor 99.46% Unkown
HY-176862 TCB-32 / Unkown
HY-50904S Nintedanib-d3 Inhibitor / Unkown
HY-RS04913 Fgfr1 Rat Pre-designed siRNA Set A / Unkown
HY-10184 TG 100572 Inhibitor / Unkown
HY-12965A S49076 hydrochloride Inhibitor / Unkown
HY-10407G SU 5402 (GMP) Inhibitor / Unkown
HY-183960 BPyO-34 Inhibitor / Unkown
HY-101544 ARQ 069 Inhibitor / Unkown
HY-10208S1 Pazopanib-13C,d3 / Unkown
HY-10335 BMS-645737 Inhibitor / Unkown
HY-10981S1 Lenvatinib-d5 Inhibitor / Unkown
HY-10981S2 Lenvatinib-15N,d4 Inhibitor 98.01% Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-116059 EGFR-IN-199 Inhibitor / Unkown
HY-122833 FGFR3-IN-10 Inhibitor / Unkown
HY-122888 MPT0L145 / Unkown
HY-123134 FIIN-4 Inhibitor / Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-139376 FGFR1 inhibitor-2 Inhibitor / Unkown
HY-142921 FGFR-IN-2 Inhibitor / Unkown
HY-143272 FGFR1 inhibitor-6 Inhibitor / Unkown
HY-146541 FGFR4-IN-10 Inhibitor / Unkown
HY-147713 FGFR3-IN-1 Inhibitor / Unkown
HY-147715 FGFR3-IN-3 Inhibitor / Unkown
HY-148778 FGFR3-IN-4 Inhibitor / Unkown
HY-149415 Multi-kinase-IN-5 Inhibitor / Unkown
HY-149486 FGFR1 inhibitor 7 Inhibitor / Unkown
HY-149487 FGFR1 inhibitor-8 Inhibitor / Unkown
HY-149488 FGFR1 inhibitor-9 Inhibitor / Unkown
HY-149512 FGFR1/VEGFR2-IN-1 Inhibitor / Unkown
HY-150026 Multi-kinase-IN-2 / Unkown
HY-150652 FGFR-IN-8 / Unkown
HY-151903S FGFR2/3-IN-1 Inhibitor / Unkown
HY-151969 VEGFR-2-IN-30 Inhibitor / Unkown
HY-152104 FGFR-IN-9 Inhibitor / Unkown
HY-152146 HDAC-IN-50 / Unkown
HY-155028 FGFR-IN-11 Inhibitor / Unkown
HY-158027 B-Raf IN 17 Inhibitor / Unkown
HY-158098 FGFR1 inhibitor-11 Inhibitor / Unkown
HY-161841 Antitumor agent-177 Inhibitor / Unkown
HY-161995 FGFR1/VEGFR2-IN-2 / Unkown
HY-162577 FGFR-IN-14 Inhibitor / Unkown
HY-163273 FGFR4-IN-17 Inhibitor / Unkown
HY-163527 FGFR-IN-13 Inhibitor / Unkown
HY-168286 FGFR-IN-16 Inhibitor / Unkown
HY-168597 FGFR1/VEGFR2-IN-3 / Unkown
HY-168653 FGFR-IN-15 Inhibitor / Unkown
HY-169623 FGFR1 inhibitor-14 Inhibitor / Unkown
HY-170846 FGFRs-IN-1 Inhibitor / Unkown
HY-170869 PROTAC FGFR1 degrader-1 Degrader / Unkown
HY-170919 FGFR2/3-IN-2 Inhibitor / Unkown
HY-170934 BW710 Inhibitor / Unkown
HY-172618 FGFR1 inhibitor-18 Inhibitor / Unkown
HY-172921 FGFR-IN-18 Inhibitor / Unkown
HY-172922 FGFR-IN-19 Inhibitor / Unkown
HY-174154 INCB126503 Inhibitor / Unkown
HY-177276 FGFR-IN-22 Inhibitor / Unkown
HY-178059 FGFR-IN-23 / Unkown
HY-179381 FGFR4-IN-24 Inhibitor / Unkown
HY-181005 FGFR-IN-25 / Unkown
HY-181031 FGFR-IN-24 / Unkown
HY-181752 FGFR3-IN-12 / Unkown
HY-182817 Len-604 / Unkown
HY-182915 FGFR-IN-26 Inhibitor / Unkown
HY-183684 RET-IN-33 Inhibitor / Unkown
HY-183780 FGFR-IN-27 / Unkown
HY-402309 IGF-1R modulator 1 Modulator / Unkown
HY-50905S Dovitinib-d8 Inhibitor / Unkown
HY-E70717 FGFR1 V561M Recombinant Human Active Protein Kinase / Unkown
HY-N0060S1 Ferulic acid-13C3 Inhibitor 98.3% Unkown
HY-P10870 Pep1-DNP conjugate 9 / Unkown
HY-RS04914 FGFR1OP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W758126 (R)-Brivanib alaninate-d4 / Unkown
HY-W801893 FGFR1 inhibitor-13 Inhibitor / Unkown
HY-10208S2 Pazopanib-d3 / Unkown
HY-123453 SM27 Inhibitor / Unkown
HY-15599A SSR128129E free acid Inhibitor / Unkown
HY-159503A Segigratinib hydrochloride Inhibitor / Unkown
HY-164459 AZ8010 Inhibitor / Unkown
HY-169669 FGFR1 inhibitor-17 Inhibitor / Unkown
HY-169710 FGFR1 inhibitor-16 Inhibitor / Unkown
HY-174690 Human FGFR1 mRNA / Unkown
HY-18817 AFG210 Inhibitor / Unkown
HY-W261325 FGFR1 inhibitor-15 Inhibitor / Unkown
HY-W705479 Pazopanib-d3 hydrochloride / Unkown
HY-W754878 Pemigatinib-d6 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990964 Efimosfermin alfa 99% Unkown
HY-P991999 OM-RCA-01 ≥99.0% Unkown
HY-P990415 Anti-FGFR1/CD331 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens FGFR1 NCBI NCBI:2260