Slc9a3 - solute carrier family 9 (sodium/hydrogen exchanger), member 3 Gene

Also Known as NHE3; NHE-3; 9030624O13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105243

Summary

Enables PDZ domain binding activity and sodium:proton antiporter activity. Acts upstream of or within regulation of pH and sodium ion transport. Located in apical plasma membrane; brush border membrane; and vesicle. Is expressed in early conceptus; liver; metanephros; and oocyte. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a3 Products (1)

mRNA Protein Name
NM_001081060.3 NP_001074529.1 sodium/hydrogen exchanger 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
16141316 MGI
enables sodium:proton antiporter activity IDA
IDA: Inferred from direct assay
10666043 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of pH IDA
IDA: Inferred from direct assay
10666043 MGI
acts upstream of or within sodium ion transport IDA
IDA: Inferred from direct assay
10666043 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12169661 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
16141316 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16141316 MGI
located in vesicle IDA
IDA: Inferred from direct assay
23863468 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13343 SLC9A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc9a3 NCBI NCBI:6550