Cacng2 - calcium channel, voltage-dependent, gamma subunit 2 Gene

Also Known as stg; wag; waggler; stargazer; stargazin; B230105C07Rik; B930041E13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12300

Summary

Enables voltage-gated Calcium Channel activity. Involved in several processes, including neurotransmitter receptor internalization; postsynaptic neurotransmitter receptor diffusion trapping; and protein localization to organelle. Acts upstream of or within several processes, including membrane hyperpolarization; neuromuscular junction development; and transmission of nerve impulse. Located in hippocampal mossy fiber to CA3 synapse and somatodendritic compartment. Is integral component of postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including eye; genitourinary system; ileum; nervous system; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Cacng2 Products (1)

mRNA Protein Name
NM_007583.2 NP_031609.1 voltage-dependent calcium channel gamma-2 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20805473 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
12151514 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
9065835 MGI
acts upstream of or within membrane hyperpolarization IMP
IMP: Inferred from mutant phenotype
9065835 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
9293489 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
17320843 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
18753375 MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
18753375 MGI
involved in postsynaptic neurotransmitter receptor diffusion trapping IDA
IDA: Inferred from direct assay
17329211 MGI
involved in postsynaptic neurotransmitter receptor diffusion trapping IMP
IMP: Inferred from mutant phenotype
17329211 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
12151514 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
11140673 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: Inferred from expression pattern
11140673 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
11140673 MGI
acts upstream of or within transmission of nerve impulse IGI
IGI: Inferred from genetic interaction
15677329 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
27076426 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11140673 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
11140673 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11140673 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
11140673 MGI
is active in hippocampal mossy fiber to CA3 synapse IEP
IEP: Inferred from expression pattern
11140673 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
11140673 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
27076426 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
18341993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-2 subunit

  • TARP gamma-2

  • neuronal voltage-gated calcium channel gamma-2 subunit

  • transmembrane AMPAR regulatory protein gamma-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01810 CACNG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacng2 NCBI NCBI:10369