2. Gene
  3. Fgd1 - FYVE, RhoGEF and PH domain containing 1 Gene

Fgd1 - FYVE, RhoGEF and PH domain containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ZFYVE3

Gene ID: 14163 | Gene type: protein coding

About Fgd1

Summary

This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin Cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]

Fgd1 Products(1)

mRNA Protein Name
NM_008001.4 NP_032027.2 FYVE, RhoGEF and PH domain-containing protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12913069 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cytoskeleton organization IDA
IDA: Inferred from direct assay
12913069 MGI
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
12913069 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12913069 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12913069 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12913069 MGI
located in ruffle IDA
IDA: Inferred from direct assay
12913069 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FYVE, RhoGEF and PH domain-containing protein 1

faciogenital dysplasia 1 protein homolog

rho/Rac GEF

rho/Rac guanine nucleotide exchange factor FGD1

zinc finger FYVE domain-containing protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04880 FGD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgd1 NCBI NCBI:2245