DGKB - diacylglycerol kinase beta Gene

Homo sapiens

Also known as DGK; DAGK2; DGK-BETA

Gene ID: 1607 | Gene type: protein coding

About DGKB

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:14,145,049-14,974,858 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 9 paralogues. Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues.

Summary

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

DGKB Products(19)

mRNA	Protein	Name
NM_001350705.1	NP_001337634.1	diacylglycerol kinase beta isoform 1
NM_001350706.2	NP_001337635.1	diacylglycerol kinase beta isoform 1
NM_001350707.2	NP_001337636.1	diacylglycerol kinase beta isoform 3
NM_001350708.1	NP_001337637.1	diacylglycerol kinase beta isoform 3
NM_001350709.2	NP_001337638.1	diacylglycerol kinase beta isoform 3
NM_001350711.2	NP_001337640.1	diacylglycerol kinase beta isoform 4
NM_001350712.1	NP_001337641.1	diacylglycerol kinase beta isoform 4
NM_001350714.2	NP_001337643.1	diacylglycerol kinase beta isoform 4
NM_001350715.1	NP_001337644.1	diacylglycerol kinase beta isoform 5
NM_001350716.2	NP_001337645.1	diacylglycerol kinase beta isoform 5
NM_001350717.2	NP_001337646.1	diacylglycerol kinase beta isoform 6
NM_001350718.1	NP_001337647.1	diacylglycerol kinase beta isoform 6
NM_001350719.2	NP_001337648.1	diacylglycerol kinase beta isoform 6
NM_001350720.1	NP_001337649.1	diacylglycerol kinase beta isoform 7
NM_001350721.2	NP_001337650.1	diacylglycerol kinase beta isoform 7
NM_001350722.2	NP_001337651.1	diacylglycerol kinase beta isoform 8
NM_001350723.2	NP_001337652.1	diacylglycerol kinase beta isoform 8
NM_001350724.2	NP_001337653.1	diacylglycerol kinase beta isoform 9
NM_145695.2	NP_663733.1	diacylglycerol kinase beta isoform 2

DGKB Protein Structure

DAG_kinase_N

EF-hand_7

C1_1

DAGK_cat

DAGK_acc

0
200
400
600
804 a.a.

Protein Preferred Names

Protein Names

diacylglycerol kinase beta

90 kDa diacylglycerol kinase

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells	HPS1
Delta Storage Pool Disease	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Hermansky-Pudlak Syndrome, Type 1	Platelet Storage Pool Deficiency

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03716	DGKB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DGKB	VGNC	VGNC:102575
Bos taurus	DGKB	VGNC	VGNC:28025
Macaca mulatta	DGKB	VGNC	VGNC:71782
Rattus norvegicus	DGKB	RGD	RGD:2488
Mus musculus	DGKB	MGD	MGI:2442474
Canis familiaris	DGKB	VGNC	VGNC:39916