DGKB - diacylglycerol kinase beta Gene

Also Known as DGK; DAGK2; DGK-BETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1607

About DGKB

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:14,145,049-14,974,858 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 9 paralogues. Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues.

Summary

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

DGKB Products (19)

mRNA Protein Name
NM_001350705.1 NP_001337634.1 diacylglycerol kinase beta isoform 1
NM_001350706.2 NP_001337635.1 diacylglycerol kinase beta isoform 1
NM_001350707.2 NP_001337636.1 diacylglycerol kinase beta isoform 3
NM_001350708.1 NP_001337637.1 diacylglycerol kinase beta isoform 3
NM_001350709.2 NP_001337638.1 diacylglycerol kinase beta isoform 3
NM_001350711.2 NP_001337640.1 diacylglycerol kinase beta isoform 4
NM_001350712.1 NP_001337641.1 diacylglycerol kinase beta isoform 4
NM_001350714.2 NP_001337643.1 diacylglycerol kinase beta isoform 4
NM_001350715.1 NP_001337644.1 diacylglycerol kinase beta isoform 5
NM_001350716.2 NP_001337645.1 diacylglycerol kinase beta isoform 5
NM_001350717.2 NP_001337646.1 diacylglycerol kinase beta isoform 6
NM_001350718.1 NP_001337647.1 diacylglycerol kinase beta isoform 6
NM_001350719.2 NP_001337648.1 diacylglycerol kinase beta isoform 6
NM_001350720.1 NP_001337649.1 diacylglycerol kinase beta isoform 7
NM_001350721.2 NP_001337650.1 diacylglycerol kinase beta isoform 7
NM_001350722.2 NP_001337651.1 diacylglycerol kinase beta isoform 8
NM_001350723.2 NP_001337652.1 diacylglycerol kinase beta isoform 8
NM_001350724.2 NP_001337653.1 diacylglycerol kinase beta isoform 9
NM_145695.2 NP_663733.1 diacylglycerol kinase beta isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
11719522 GOA
enables lipid binding IDA
IDA: Inferred from direct assay
22627129 GOA
Biological Process GO Annotation Evidence References Source
involved in glycerolipid metabolic process IDA
IDA: Inferred from direct assay
22627129 GOA
involved in lipid phosphorylation IDA
IDA: Inferred from direct assay
11719522 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11719522 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
11719522 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11719522 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKB Protein Structure

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (3 - 149)

EF-hand_7

EF-hand_7: EF-hand domain pair (154 - 221)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (245 - 295)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (310 - 360)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (438 - 562)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (583 - 762)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase beta

  • 90 kDa diacylglycerol kinase

Related Diseases

Diseases Alias
Hermansky-Pudlak Syndrome 1

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • HPS1

  • Delta Storage Pool Disease

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Hermansky-Pudlak Syndrome, Type 1

  • Platelet Storage Pool Deficiency
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03716 DGKB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20268 Dgkb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26776 Dgkb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DGKB VGNC VGNC:102575
Bos taurus DGKB VGNC VGNC:28025
Macaca mulatta DGKB VGNC VGNC:71782
Rattus norvegicus DGKB RGD RGD:2488
Mus musculus DGKB MGD MGI:2442474
Canis familiaris DGKB VGNC VGNC:39916
Others DGKB NCBI