SLC5A8 - solute carrier family 5 member 8 Gene

Also Known as AIT; SMCT; SMCT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 160728

About SLC5A8

Cytogenetic location: 12q23.1-q23.2 Genomic coordinates (GRCh38): 12:101,155,493-101,210,238 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 263 orthologues and 11 paralogues. Biased expression in thyroid (RPKM 19.8), kidney (RPKM 2.8) and 1 other tissue.

Summary

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

SLC5A8 Products (1)

mRNA Protein Name
NM_145913.5 NP_666018.3 sodium-coupled monocarboxylate transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monocarboxylate:sodium symporter activity IDA
IDA: Inferred from direct assay
14966140 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30604288 GOA
Biological Process GO Annotation Evidence References Source
involved in acetate transport IDA
IDA: Inferred from direct assay
14966140 GOA
involved in chloride transport IDA
IDA: Inferred from direct assay
19864324 GOA
involved in iodide transport IDA
IDA: Inferred from direct assay
12107270 GOA
involved in lactate transport IDA
IDA: Inferred from direct assay
14966140 GOA
involved in nicotinate transport IDA
IDA: Inferred from direct assay
14966140 GOA
involved in nitrate transmembrane transport IDA
IDA: Inferred from direct assay
19864324 GOA
involved in propanoate transmembrane transport IDA
IDA: Inferred from direct assay
14966140 GOA
involved in pyruvate transport IDA
IDA: Inferred from direct assay
14966140 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12107270 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC5A8 Protein Structure

SSF

SSF: Sodium:solute symporter family (45 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 610 a.a.
Protein Preferred Names Protein Names

sodium-coupled monocarboxylate transporter 1

  • apical iodide transporter

Related Diseases

Diseases Alias
Pancreatic Colloid Cystadenoma

  • Mucinous Cystadenoma Of Pancreas
Pellagra

  • Niacin Deficiency

  • Niacin-Tryptophan Deficiency

  • Pellagroid Syndrome
Diversion Colitis
Fetal Adenoma

  • Microfollicular Adenoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13294 SLC5A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC5A8 VGNC VGNC:77737
Bos taurus SLC5A8 VGNC VGNC:34911
Canis familiaris SLC5A8 VGNC VGNC:46451
Rattus norvegicus SLC5A8 RGD RGD:1564146
Felis catus SLC5A8 VGNC VGNC:65406
Mus musculus SLC5A8 MGD MGI:2384916
Others SLC5A8 NCBI