DNAH10 - dynein axonemal heavy chain 10 Gene

Also Known as SPGF56

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196385

About DNAH10

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,762,301-123,935,720 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 238 orthologues, 15 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 3.1), bone marrow (RPKM 0.9) and 3 other tissues.

Summary

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]

DNAH10 Products (2)

mRNA Protein Name
NM_001372106.1 NP_001359035.1 dynein axonemal heavy chain 10 isoform 3
NM_207437.3 NP_997320.2 dynein axonemal heavy chain 10 isoform 1

DNAH10 Protein Structure

DHC_N1

DHC_N1: Dynein heavy chain, N-terminal region 1 (241 - 540)

DHC_N1

DHC_N1: Dynein heavy chain, N-terminal region 1 (545 - 759)

DHC_N2

DHC_N2: Dynein heavy chain, N-terminal region 2 (1253 - 1663)

AAA_6

AAA_6: Hydrolytic ATP binding site of dynein motor region D1 (1794 - 2023)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (2110 - 2244)

AAA_7

AAA_7: P-loop containing dynein motor region D3 (2420 - 2686)

AAA_8

AAA_8: P-loop containing dynein motor region D4 (2766 - 3033)

MT

MT: Microtubule-binding stalk of dynein motor (3046 - 3379)

AAA_9

AAA_9: ATP-binding dynein motor region D5 (3398 - 3628)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (3761 - 4468)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4200
  • 4471 a.a.
Protein Preferred Names Protein Names

dynein axonemal heavy chain 10

  • axonemal beta dynein heavy chain 10

Related Diseases

Diseases Alias
Spermatogenic Failure 56

  • SPGF56
Spermatogenic Failure 5

  • Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

  • SPGF5

  • Macrocephalic Sperm Head Syndrome

  • Male Infertility Due To Macrozoospermia

  • Infertility Associated With Multitailed Spermatozoa And Excessive Dna

  • Macrozoospermia

  • Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

  • Large-Headed Multiflagellar Polyploid Spermatozoa

  • Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Lipodystrophy, Familial Partial, Type 1

  • FPLD1

  • Familial Partial Lipodystrophy Type 1

  • Familial Partial Lipodystrophy, Kobberling Type

  • Lipodystrophy, Familial Partial, Kobberling Type

  • Familial Partial Lipodystrophy Kobberling Type

  • Familial Partial Lipodystrophy Type Köbberling

  • Familial Partial Lipodystrophy, Köbberling Type

  • Familial Partial Lipodystrophy, Type 1
Congenital Anomalies Of Kidney And Urinary Tract Syndrome With Or Without Hearing Loss, Abnormal Ears, Or Developmental Delay

  • CAKUTHED

  • Doid:0112359

  • Anomalies, Congenital, Kidney And Urinary Tract Syndrome With/Without Hearing Loss, Abnormal Ears, Or Developmental Delay
Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Chronic Purulent Otitis Media

  • Chronic Suppurative Otitis Media

  • Csom - [Chronic Suppurative Otitis Media]
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03843 DNAH10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DNAH10 VGNC VGNC:61542
Canis familiaris DNAH10 VGNC VGNC:40012
Mus musculus DNAH10 MGD MGI:1860299
Bos taurus DNAH10 VGNC VGNC:28123
Rattus norvegicus DNAH10 RGD RGD:619988
Others DNAH10 NCBI