2. Gene
  3. Oas1b - 2'-5' oligoadenylate synthetase 1B Gene

Oas1b - 2'-5' oligoadenylate synthetase 1B Gene

  • Gene
  • Protein
  • Agent
Mus musculus

Also known as L1; Flv; Wnv; Oas1; Oias2; Mmu-L1; Oias-2

Gene ID: 23961 | Gene type: protein coding

About Oas1b

Summary

This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate Antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to Flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]

Oas1b Products(1)

mRNA Protein Name
NM_001083925.1 NP_001077394.1 inactive 2'-5'-oligoadenylate synthase 1B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
NOT enables 2'-5'-oligoadenylate synthetase activity IDA
IDA: Inferred from direct assay
12396720 MGI
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
12396720 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22623793 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
16371364 MGI
acts upstream of or within response to virus IDA
IDA: Inferred from direct assay
12080145 MGI
involved in response to virus IDA
IDA: Inferred from direct assay
16371364 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
22623793 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive 2'-5'-oligoadenylate synthase 1B

(2-5')oligo(A) synthase 1B

(2-5')oligo(A) synthetase 1b

2'-5'-oligoadenylate synthase-like protein 1

2'-5'-oligoadenylate synthetase-like protein 1

2-5A synthase 1B

2-5A synthetase 1B

Flavivirus resistance

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09727 OAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown