Nefm - neurofilament medium chain Gene

Also Known as Nfm; Nef3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24588

Summary

Enables signaling receptor binding activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; intermediate filament Cytoskeleton organization; and nervous system development. Located in axon; neurofilament; and perikaryon. Used to study amyotrophic lateral sclerosis and congenital hypothyroidism. Biomarker of hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefm Products (1)

mRNA Protein Name
NM_017029.2 NP_058725.1 neurofilament medium polypeptide

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9388258 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
12122054 RGD
enables toxic substance binding IDA
IDA: Inferred from direct assay
9221839 RGD
Biological Process GO Annotation Evidence References Source
involved in axon regeneration IEP
IEP: Inferred from expression pattern
15206821 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
17401155 RGD
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
17401155 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
10439464 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
14620872 RGD
involved in intermediate filament polymerization or depolymerization IDA
IDA: Inferred from direct assay
10362553 RGD
involved in neurofilament bundle assembly IDA
IDA: Inferred from direct assay
7721944 RGD
involved in response to acrylamide IEP
IEP: Inferred from expression pattern
17043767 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
2108255 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
19563171 RGD
located in cytoskeleton IDA
IDA: Inferred from direct assay
1321159 RGD
located in intermediate filament IDA
IDA: Inferred from direct assay
1321159 RGD
located in neurofilament IDA
IDA: Inferred from direct assay
7721944 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
8544917 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurofilament medium polypeptide

  • 160 kDa neurofilament protein

  • NF-M

  • Neurofilament protein, middle polypeptide

  • neurofilament 3, medium

  • neurofilament triplet M protein

  • neurofilament, medium polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10971 Nef-M1 98.87% Unkown
HY-RS09185 NEFM Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nefm NCBI NCBI:4741