Nefm - neurofilament medium chain Gene

Rattus norvegicus

Also known as Nfm; Nef3

Gene ID: 24588 | Gene type: protein coding

About Nefm

Summary

Enables signaling receptor binding activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; intermediate filament Cytoskeleton organization; and nervous system development. Located in axon; neurofilament; and perikaryon. Used to study amyotrophic lateral sclerosis and congenital hypothyroidism. Biomarker of hypothyroidism; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefm Products(1)

mRNA	Protein	Name
NM_017029.2	NP_058725.1	neurofilament medium polypeptide

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9388258	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12122054	RGD
enables toxic substance binding	IDA IDA: Inferred from direct assay	9221839	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon regeneration	IEP IEP: Inferred from expression pattern	15206821	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	17401155	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	17401155	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	10439464	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	14620872	RGD
involved in intermediate filament polymerization or depolymerization	IDA IDA: Inferred from direct assay	10362553	RGD
involved in neurofilament bundle assembly	IDA IDA: Inferred from direct assay	7721944	RGD
involved in response to acrylamide	IEP IEP: Inferred from expression pattern	17043767	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	2108255	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19563171	RGD
located in cytoskeleton	IDA IDA: Inferred from direct assay	1321159	RGD
located in intermediate filament	IDA IDA: Inferred from direct assay	1321159	RGD
located in neurofilament	IDA IDA: Inferred from direct assay	7721944	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	8544917	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurofilament medium polypeptide

160 kDa neurofilament protein	NF-M
Neurofilament protein, middle polypeptide	neurofilament 3, medium
neurofilament triplet M protein	neurofilament, medium polypeptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10971	Nef-M1		/	Unkown
HY-RS09185	NEFM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nefm	NCBI	NCBI:4741

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