2. Gene
  3. Gtf3a - general transcription factor III A Gene

Gtf3a - general transcription factor III A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 246299 | Gene type: protein coding

About Gtf3a

Summary

The product of this gene is a Zinc Finger Protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

Gtf3a Products(2)

mRNA Protein Name
NM_001113570.1 NP_001107042.1 transcription factor IIIA
NM_001113570.1 NP_001107042.1 transcription factor IIIA
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
11814676 RGD
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: Inferred from direct assay
11814676 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10756201 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor IIIA

TFIIIA

factor A

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05905 GTF3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gtf3a NCBI NCBI:2971