Sftpa1 - surfactant protein A1 Gene

Also Known as PSAP; SP-A; PSP-A; Sftp1; Sftpa; Sftpl

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24773

Summary

Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of asthma; Bacterial pneumonia; lung disease; newborn respiratory distress syndrome; and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA1 (surfactant protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Sftpa1 Products (3)

mRNA	Protein	Name
NM_001270645.1	NP_001257574.1	pulmonary surfactant-associated protein A isoform 1 precursor
NM_001270647.1	NP_001257576.1	pulmonary surfactant-associated protein A isoform 3 precursor
NM_017329.2	NP_059025.2	pulmonary surfactant-associated protein A isoform 2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	12600831	RGD
involved in cellular response to nitric oxide	IEP IEP: Inferred from expression pattern	15640287	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	12872443	RGD
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	15187139	RGD
involved in response to epidermal growth factor	IEP IEP: Inferred from expression pattern	19781387	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	2015097	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	9779374	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	11472975	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14756961	RGD
involved in response to interleukin-6	IEP IEP: Inferred from expression pattern	11000512	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11000512	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	9505268	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	10385596	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11472975	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	16187065	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pulmonary surfactant-associated protein A	Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A) pulmonary surfactant-associated protein A-like surfactant, pulmonary-associated protein A1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12780	SFTPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sftpa1	NCBI	NCBI:653509