2. Gene
  3. Sftpa1 - surfactant protein A1 Gene

Sftpa1 - surfactant protein A1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PSAP; SP-A; PSP-A; Sftp1; Sftpa; Sftpl

Gene ID: 24773 | Gene type: protein coding

About Sftpa1

Summary

Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of asthma; Bacterial pneumonia; lung disease; newborn respiratory distress syndrome; and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA1 (surfactant protein A1). [provided by Alliance of Genome Resources, Apr 2022]

Sftpa1 Products(3)

mRNA Protein Name
NM_001270645.1 NP_001257574.1 pulmonary surfactant-associated protein A isoform 1 precursor
NM_001270647.1 NP_001257576.1 pulmonary surfactant-associated protein A isoform 3 precursor
NM_017329.2 NP_059025.2 pulmonary surfactant-associated protein A isoform 2 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
12600831 RGD
involved in cellular response to nitric oxide IEP
IEP: Inferred from expression pattern
15640287 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12872443 RGD
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
15187139 RGD
involved in response to epidermal growth factor IEP
IEP: Inferred from expression pattern
19781387 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
2015097 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
9779374 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
11472975 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
14756961 RGD
involved in response to interleukin-6 IEP
IEP: Inferred from expression pattern
11000512 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11000512 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
9505268 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
10385596 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
11472975 RGD
located in multivesicular body IDA
IDA: Inferred from direct assay
16187065 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pulmonary surfactant-associated protein A

Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A)

pulmonary surfactant-associated protein A-like

surfactant, pulmonary-associated protein A1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12780 SFTPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sftpa1 NCBI NCBI:653509