Itpr1 - inositol 1,4,5-trisphosphate receptor, type 1 Gene

Also Known as P400; IP3R1; I145TR; InsP3R; InsP3R1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25262

Summary

This gene belongs to the Insp3 receptor family. It encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Itpr1 Products (3)

mRNA	Protein	Name
NM_001007235.2	NP_001007236.2	inositol 1,4,5-trisphosphate receptor type 1 isoform 1
NM_001270596.1	NP_001257525.1	inositol 1,4,5-trisphosphate receptor type 1 isoform 2
NM_001270597.1	NP_001257526.1	inositol 1,4,5-trisphosphate receptor type 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	36376291	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	21827954	RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA IDA: Inferred from direct assay	15533917	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12676536	RGD
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	15212990	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15212990	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	23982204	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in calcium import into the mitochondrion	IMP IMP: Inferred from mutant phenotype	17178908	RGD
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	20189985	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	17285299	RGD
involved in dendrite development	IEP IEP: Inferred from expression pattern	19236309	RGD
involved in liver regeneration	IMP IMP: Inferred from mutant phenotype	24814243	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20434434	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28072885	RGD
involved in positive regulation of calcium ion transport	IDA IDA: Inferred from direct assay	19036964	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15911880	RGD
involved in positive regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	24814243	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	21211516	RGD
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	36376291	RGD
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	16223735	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	1311032	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17471556	RGD
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10506212	RGD
is active in membrane	IDA IDA: Inferred from direct assay	1311032	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17471556	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	16014380	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12615969	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	1311032	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	1311032	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12676536	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	16014380	RGD
is active in smooth endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	1311032	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	12676536	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
inositol 1,4,5-trisphosphate receptor type 1	IP-3-R IP3 receptor IP3R 1 inositol 1,4,5-triphosphate receptor 1 inositol 1,4,5-triphosphate receptor, type 1 type 1 InsP3 receptor type 1 inositol 1,4,5-trisphosphate receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163171	ARN11391		99.40%	Unkown
HY-RS29492	Itpr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06991	ITPR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itpr1	NCBI	NCBI:3708