AMD1 - adenosylmethionine decarboxylase 1 Gene

Homo sapiens

Also known as AMD; SAMDC; ADOMETDC

Gene ID: 262 | Gene type: protein coding

About AMD1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,814,617-110,895,713 (from NCBI)

This gene has 10 transcripts (splice variants) and 256 orthologues. Ubiquitous expression in prostate (RPKM 106.1), bone marrow (RPKM 38.6) and 25 other tissues.

Summary

This gene encodes an important intermediate Enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

AMD1 Products(7)

mRNA	Protein	Name
NM_001287214.1	NP_001274143.1	S-adenosylmethionine decarboxylase proenzyme isoform 3
NM_001287215.2	NP_001274144.1	S-adenosylmethionine decarboxylase proenzyme isoform 4
NM_001287216.1	NP_001274145.1	S-adenosylmethionine decarboxylase proenzyme isoform 5
NM_001393406.1	NP_001380335.1	S-adenosylmethionine decarboxylase proenzyme isoform 4
NM_001393407.1	NP_001380336.1	S-adenosylmethionine decarboxylase proenzyme isoform 6
NM_001393408.1	NP_001380337.1	S-adenosylmethionine decarboxylase proenzyme isoform 6
NM_001634.6	NP_001625.2	S-adenosylmethionine decarboxylase proenzyme isoform 1

AMD1 Protein Structure

SAM_decarbox

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

S-adenosylmethionine decarboxylase proenzyme

S-adenosylmethionine decarboxylase 1

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 87

DEE87	Epileptic Encephalopathy, Early Infantile, 87
Eiee87	Developmental And Epileptic Encephalopathy, 87
Early Infantile Epileptic Encephalopathy 87

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Trypanosomiasis

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Secondary Progressive Multiple Sclerosis

Secondary-Progressive Ms	Spms
Multiple Sclerosis, Chronic Progressive	Chronic Progressive Multiple Sclerosis
Multiple Sclerosis, Secondary Progressive

Transient Cerebral Ischemia

Transient Ischemic Attack	Transient Ischemic Attacks
Tia	Tia - Transient Ischaemic Attack
Transient Cerebral Ischaemia	Ischemic Attack, Transient
Intermittent Cerebral Ischemia	Tia - [Transient Ischaemic Attack]
Intermittent Cerebral Ischaemia	Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Retinitis Pigmentosa 61

RP61	Retinitis Pigmentosa, Type 61

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109561	Pegaptanib sodium	Inhibitor	98.09%	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-15492	AG-13958	Inhibitor	99.71%	Unkown
HY-RS00644	AMD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AMD1	VGNC	VGNC:37827
Macaca mulatta	AMD1	VGNC	VGNC:81021
Bos taurus	AMD1	VGNC	VGNC:25859
Mus musculus	AMD1	MGD	MGI:88004
Rattus norvegicus	AMD1	RGD	RGD:2104
Others	AMD1	NCBI

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