Emixustat hydrochloride (Synonyms: ACU-4429 hydrochloride)

Cat. No.: HY-19720A Purity: 99.59%: FAQs
Data Sheet SDS COA Handling Instructions

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Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM.

For research use only. We do not sell to patients.

Emixustat hydrochloride Chemical Structure

CAS No. : 1141934-97-5

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10 mM * 1 mL in DMSO ready for reconstitution	USD 165	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 165	In-stock	Estimated Time of Arrival: December 31
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2 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 595	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Emixustat hydrochloride:

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Description

Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. IC50 value: 232 nM [1] Target: 11-cis-retinol Emixustat hydrochloride is a novel visual cycle modulator, in healthy volunteers. Oral Emixustat was safe and well tolerated when administered once daily for 14 days with minimal systemic adverse events reported. Evaluation of emixustat in subjects with geographic atrophy associated with dry age-related macular degeneration.[2]

Clinical Trial

Molecular Weight

299.84

Formula

C₁₆H₂₆ClNO₂

CAS No.

1141934-97-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@H](CCN)C1=CC(OCC2CCCCC2)=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 44 mg/mL (146.74 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3351 mL	16.6756 mL	33.3511 mL
5 mM	0.6670 mL	3.3351 mL	6.6702 mL
10 mM	0.3335 mL	1.6676 mL	3.3351 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. [Content Brief]

[2]. Kubota R, et al. Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3351 mL	16.6756 mL	33.3511 mL	83.3778 mL
	5 mM	0.6670 mL	3.3351 mL	6.6702 mL	16.6756 mL
	10 mM	0.3335 mL	1.6676 mL	3.3351 mL	8.3378 mL
	15 mM	0.2223 mL	1.1117 mL	2.2234 mL	5.5585 mL
	20 mM	0.1668 mL	0.8338 mL	1.6676 mL	4.1689 mL
	25 mM	0.1334 mL	0.6670 mL	1.3340 mL	3.3351 mL
	30 mM	0.1112 mL	0.5559 mL	1.1117 mL	2.7793 mL
	40 mM	0.0834 mL	0.4169 mL	0.8338 mL	2.0844 mL
	50 mM	0.0667 mL	0.3335 mL	0.6670 mL	1.6676 mL
	60 mM	0.0556 mL	0.2779 mL	0.5559 mL	1.3896 mL
	80 mM	0.0417 mL	0.2084 mL	0.4169 mL	1.0422 mL
	100 mM	0.0334 mL	0.1668 mL	0.3335 mL	0.8338 mL

Emixustat hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emixustat1141934-97-5ACU-4429ACU4429ACU 4429OthersInhibitorinhibitorinhibit

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Emixustat hydrochloride (Synonyms: ACU-4429 hydrochloride)

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Complete Stock Solution Preparation Table

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