1141934-97-5
Chemical Structure
Emixustat hydrochloride
Synonym(s): ACU-4429 hydrochloride
- CAS No.: 1141934-97-5
- Formula:C16H26ClNO2
- Molecular Weight:299.84
IUPAC Name: (R)-3-amino-1-(3-(cyclohexylmethoxy)phenyl)propan-1-ol hydrochloride
InChIKey: BPZWRYOUJMDQSY-PKLMIRHRSA-N
SMILES: O[C@H](CCN)C1=CC(OCC2CCCCC2)=CC=C1.[H]Cl
Biological Activity: Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD)[1][2][3][4].
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Emixustat hydrochloride | 99.29% | Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD). | ||||||||||||||||||||
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- [1]. Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15. [Content Brief]
- [2]. Kubota R, et al. Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9. [Content Brief]
- [3]. Kubota R, et al. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4924-4930. [Content Brief]
- [4]. Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10(5):e0124940. [Content Brief]
Keywords
