Fgd2 - FYVE, RhoGEF and PH domain containing 2 Gene

Also Known as Tcd2; tcs2; Tcd-2; tcs-2; ZFYVE4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26382

Summary

Enables guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Acts upstream of or within positive regulation of JUN kinase activity. Located in early endosome; nucleus; and ruffle. Orthologous to human FGD2 (FYVE, RhoGEF and PH domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgd2 Products (2)

mRNA Protein Name
NM_001159538.1 NP_001153010.1 FYVE, RhoGEF and PH domain-containing protein 2 isoform 1
NM_013710.4 NP_038738.2 FYVE, RhoGEF and PH domain-containing protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
18838382 MGI
enables phosphatidylinositol phosphate binding IDA
IDA: Inferred from direct assay
18838382 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of JUN kinase activity IGI
IGI: Inferred from genetic interaction
18838382 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18838382 MGI
located in early endosome IDA
IDA: Inferred from direct assay
18838382 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18838382 MGI
located in ruffle IDA
IDA: Inferred from direct assay
18838382 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

FYVE, RhoGEF and PH domain-containing protein 2

  • Fgd1 family, member 2

  • Fgd2-like protein

  • faciogenital dysplasia homolog 2

  • faciogenital dysplasia protein 2

  • t-complex distorter 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04881 FGD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08638 MRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgd2 NCBI NCBI:221472