Plod3 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 Gene

Also Known as LH3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26433

Summary

Enables procollagen glucosyltransferase activity and procollagen-lysine 5-dioxygenase activity. Involved in hydroxylysine biosynthetic process and peptidyl-lysine hydroxylation. Acts upstream of or within several processes, including chordate embryonic development; endothelial cell morphogenesis; and extracellular matrix organization. Located in several cellular components, including collagen-containing extracellular matrix; endoplasmic reticulum; and trans-Golgi network. Is expressed in several structures, including ear; hindlimb; incisor; nasal capsule; and skeleton. Orthologous to human PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]

Plod3 Products (1)

mRNA	Protein	Name
NM_011962.3	NP_036092.1	multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables procollagen glucosyltransferase activity	IDA IDA: Inferred from direct assay	16447251	MGI
enables procollagen-lysine 5-dioxygenase activity	IDA IDA: Inferred from direct assay	16447251	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within basement membrane assembly	IMP IMP: Inferred from mutant phenotype	16467571	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	16467571	MGI
acts upstream of or within collagen metabolic process	IMP IMP: Inferred from mutant phenotype	27435297	MGI
acts upstream of or within endothelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	16467571	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	16467571	MGI
involved in hydroxylysine biosynthetic process	IDA IDA: Inferred from direct assay	16447251	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16467571	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	16467571	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	16467571	MGI
involved in peptidyl-lysine hydroxylation	IDA IDA: Inferred from direct assay	16447251	MGI
acts upstream of or within peptidyl-lysine hydroxylation	IMP IMP: Inferred from mutant phenotype	27435297	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	16467571	MGI
acts upstream of or within vasodilation	IMP IMP: Inferred from mutant phenotype	16467571	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	27435297	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16447251	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	16447251	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	27435297	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	lysyl hydroxylase 2 lysyl hydroxylase 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10730	PLOD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plod3	NCBI	NCBI:8985