DAOA - D-amino acid oxidase activator Gene

Also Known as LG72; SG72

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 267012

About DAOA

Cytogenetic location: 13q33.2 Genomic coordinates (GRCh38): 13:105,465,867-105,491,034 (from NCBI)

This gene has 11 transcripts (splice variants), 7 orthologues and is associated with 1 phenotype.

Summary

This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

DAOA Products (6)

mRNA Protein Name
NM_001161812.1 NP_001155284.1 D-amino acid oxidase activator isoform 2
NM_001161814.1 NP_001155286.1 D-amino acid oxidase activator isoform 3
NM_001384644.1 NP_001371573.1 D-amino acid oxidase activator isoform 4
NM_001384645.1 NP_001371574.1 D-amino acid oxidase activator isoform 5
NM_001384646.1 NP_001371575.1 D-amino acid oxidase activator isoform 3
NM_172370.5 NP_758958.3 D-amino acid oxidase activator isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12364586 GOA
Biological Process GO Annotation Evidence References Source
involved in D-amino acid metabolic process IDA
IDA: Inferred from direct assay
12364586 GOA
involved in positive regulation of protein catabolic process IDA
IDA: Inferred from direct assay
21679769 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12364586 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
17684499 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21679769 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAOA Protein Structure

DAOA

DAOA: D-amino acid oxidase activator (72 - 153)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

D-amino acid oxidase activator

  • schizophrenia- and bipolar disorder-associated protein G72

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Psychotic Disorder

  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders
Schizoaffective Disorder

  • Schizo-Affective Psychosis

  • Schizo-Affective Type Schizophrenia

  • Schizoaffective Psychosis

  • Schizoaffective Schizophrenia

  • Schizophrenia, Schizo-Affective Type

  • Schizophreniform Psychosis, Affective Type
Schizophrenia 7

  • SCZD7

  • Schizophrenia Susceptibility Locus, Chromosome 13q-Related

  • Schizophrenia 7 With Or Without An Affective Disorder
Schizophrenia 1

  • SCZD1

  • Schizophrenia Susceptibility Locus, Chromosome 5-Related

  • Schizophrenia 1 With Or Without An Affective Disorder
Mood Disorder

  • Mood Disorders

  • Episodic Mood Disorder
Cyclothymic Disorder

  • Cyclothymia

  • Cycloid Personality

  • Cyclothymic Personality

  • Affective Personality Disorder

  • Cyclothymic Personality Disorder

  • Cycloid Personality Disorder
Panic Disorder

  • Panic Anxiety Syndrome

  • Panic

  • Panic Disorder 1

  • Episodic Paroxysmal Anxiety Disorder
Schizotypal Personality Disorder

  • Schizotypal Personality
Bipolar I Disorder

  • Manic Depression Nos

  • Manic-Depressive Illness

  • Bipolar Disorder Nos
Schizophreniform Disorder

  • Schizophreniform Disorders

  • Psychotic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03524 DAOA Human Pre-designed siRNA Set A Pre-designed Set / Unkown