DAOA - D-amino acid oxidase activator Gene

Homo sapiens

Also known as LG72; SG72

Gene ID: 267012 | Gene type: protein coding

About DAOA

Cytogenetic location: 13q33.2 Genomic coordinates (GRCh38): 13:105,465,867-105,491,034 (from NCBI)

This gene has 11 transcripts (splice variants), 7 orthologues and is associated with 1 phenotype.

Summary

This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

DAOA Products(6)

mRNA	Protein	Name
NM_001161812.1	NP_001155284.1	D-amino acid oxidase activator isoform 2
NM_001161814.1	NP_001155286.1	D-amino acid oxidase activator isoform 3
NM_001384644.1	NP_001371573.1	D-amino acid oxidase activator isoform 4
NM_001384645.1	NP_001371574.1	D-amino acid oxidase activator isoform 5
NM_001384646.1	NP_001371575.1	D-amino acid oxidase activator isoform 3
NM_172370.5	NP_758958.3	D-amino acid oxidase activator isoform 1

DAOA Protein Structure

DAOA

0
100
153 a.a.

Protein Preferred Names

Protein Names

D-amino acid oxidase activator

schizophrenia- and bipolar disorder-associated protein G72

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Schizophrenia 7

SCZD7	Schizophrenia Susceptibility Locus, Chromosome 13q-Related
Schizophrenia 7 With Or Without An Affective Disorder

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Cyclothymic Disorder

Cyclothymia	Cycloid Personality
Cyclothymic Personality	Affective Personality Disorder
Cyclothymic Personality Disorder	Cycloid Personality Disorder

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Schizotypal Personality Disorder

Schizotypal Personality

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders