Sh2d1b1 - SH2 domain containing 1B1 Gene

Mus musculus

Also known as Eat2; EAT-2; Eat2a; EAT-2A; Sh2d1b

Gene ID: 26904 | Gene type: protein coding

About Sh2d1b1

Summary

Enables phosphotyrosine residue binding activity. Involved in leukocyte activation involved in immune response and positive regulation of natural killer cell mediated immunity. Acts upstream of or within several processes, including natural killer cell inhibitory signaling pathway; regulation of natural killer cell mediated cytotoxicity; and regulation of peptidyl-tyrosine phosphorylation. Orthologous to human SH2D1B (SH2 domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]

Sh2d1b1 Products(1)

mRNA	Protein	Name
NM_012009.5	NP_036139.3	SH2 domain-containing protein 1B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphotyrosine residue binding	IDA IDA: Inferred from direct assay	9000139	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16127454	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in leukocyte activation involved in immune response	IDA IDA: Inferred from direct assay	21149608	MGI
acts upstream of or within natural killer cell inhibitory signaling pathway	IMP IMP: Inferred from mutant phenotype	16127454	MGI
acts upstream of natural killer cell mediated cytotoxicity	IGI IGI: Inferred from genetic interaction	19648922	MGI
acts upstream of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16127454	MGI
acts upstream of or within negative regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	16127454	MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	16127454	MGI
acts upstream of or within negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16127454	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	16425036	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	16127454	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	16127454	MGI
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	21149608	MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity	IGI IGI: Inferred from genetic interaction	19648922	MGI
involved in positive regulation of natural killer cell mediated immunity	IMP IMP: Inferred from mutant phenotype	20962259	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	16425036	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	16127454	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH2 domain-containing protein 1B

EWS/FLI1 activated transcript 2

SH2 domain protein 1B1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12822	SH2D1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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