MCHR1 - melanin concentrating hormone receptor 1 Gene

Also Known as SLC1; GPR24; MCH1R; SLC-1; MCH-1R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2847

About MCHR1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:40,679,484-40,682,812 (from NCBI)

This gene has 4 transcripts (splice variants), 241 orthologues and 33 paralogues. Biased expression in brain (RPKM 4.7), ovary (RPKM 1.2) and 5 other tissues.

Summary

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

MCHR1 Products (1)

mRNA Protein Name
NM_005297.4 NP_005288.4 melanin-concentrating hormone receptor 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
28154160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCHR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (126 - 380)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

melanin-concentrating hormone receptor 1

  • G protein-coupled receptor 24

  • MCH receptor 1

  • somatostatin receptor-like protein

Related Diseases

Diseases Alias
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction

  • Leptin
Meckel Syndrome, Type 1

  • Meckel Syndrome

  • Meckel-Gruber Syndrome

  • Dysencephalia Splanchnocystica

  • Meckel Syndrome 1

  • MKS1

  • Mks

  • Gruber Syndrome

  • Meckel-Gruber Syndrome, Type 1

  • Mes

  • Dysencephalia Splachnocystica

  • Meckel Gruber Syndrome

  • Meckel Syndrome Type 1
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

  • Vitiligo

  • VAMAS1

  • Slev1

  • Vtlg

  • Systemic Lupus Erythematosus, Vitiligo-Related

  • Vitiligo-Associated Multiple Autoimmune Disease 1

  • Systemic Lupus Erythematosus Vitiligo-Related
Nephronophthisis

  • Medullary Cystic Disease

  • Medullary Cystic Kidney

  • Nph

  • Nphp

  • Kidney Disease, Cystic, Medullary
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-U00257 AZD1979 Antagonist 99.59% Phase 1
HY-100318 MCHR1 antagonist 5 Antagonist 99.61% Phase 1
HY-12433A BMS-830216 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1205A MCH(human, mouse, rat) TFA Ligand 99.09% Unkown
HY-107625A SNAP 94847 hydrochloride Inhibitor 99.90% Unkown
HY-100321 MCHR1 antagonist 2 98.27% Unkown
HY-108049 GW856464 Antagonist 99.83% Unkown
HY-12433 BMS-819881 99.78% Unkown
HY-P1204 [Ala17]-MCH Agonist 98.28% Unkown
HY-RS08225 MCHR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107626 ATC0065 Antagonist 99.09% Unkown
HY-101699 AMG-076 free base Antagonist / Unkown
HY-107625 SNAP 94847 Antagonist / Unkown
HY-107626A ATC0065 free base Antagonist / Unkown
HY-116031 ATC0175 free base Antagonist / Unkown
HY-119015 MCHR1 antagonist 6 Antagonist / Unkown
HY-120608 BMS-814580 Inhibitor / Unkown
HY-120847 BI 186908 Antagonist / Unkown
HY-136152 MCHR1 antagonist 3 Antagonist / Unkown
HY-161899 MCHR1 antagonist 4 Antagonist / Unkown
HY-185478 NGD-4715 Antagonist / Unkown
HY-P1204A [Ala17]-MCH TFA Agonist / Unkown
HY-RS08226 Mchr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08227 Mchr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101699A AMG-076 Antagonist / Unkown
HY-U00353 MCHR1 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MCHR1 VGNC VGNC:95360
Mus musculus MCHR1 MGD MGI:2180756
Felis catus MCHR1 VGNC VGNC:67422
Rattus norvegicus MCHR1 RGD RGD:619841
Canis familiaris MCHR1 VGNC VGNC:43076
Bos taurus MCHR1 VGNC VGNC:31305