2. Gene
  3. Actn2 - actinin alpha 2 Gene

Actn2 - actinin alpha 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 291245 | Gene type: protein coding

About Actn2

Summary

Predicted to enable several functions, including cytoskeletal protein binding activity; nuclear receptor coactivator activity; and protein domain specific binding activity. Predicted to be involved in several processes, including focal adhesion assembly; muscle cell development; and regulation of ion transmembrane transporter activity. Predicted to act upstream of or within muscle contraction. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic density, intracellular component. Colocalizes with cortical actin Cytoskeleton. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and dilated cardiomyopathy 1AA. Orthologous to human ACTN2 (actinin alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Actn2 Products(1)

mRNA Protein Name
NM_001170325.1 NP_001163796.1 alpha-actinin-2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15456832 RGD
enables structural constituent of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
25007055 RGD
enables structural constituent of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
25007055 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
15505042 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9454847 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25007055 RGD
is active in postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
9454847 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
9454847 RGD
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
9454847 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-actinin-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00224 ACTN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actn2 NCBI NCBI:88