ITSN1 - Itsn1 intersectin 1 Gene

Rattus norvegicus

Also known as Itsn; EHSH1

Gene ID: 29491 | Gene type: protein coding

About ITSN1

Summary

Predicted to enable kinase activator activity; molecular adaptor activity; and proline-rich region binding activity. Involved in several processes, including positive regulation of dendritic spine development; positive regulation of transport; and regulation of modification of postsynaptic actin Cytoskeleton. Located in several cellular components, including clathrin-coated pit; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic actin Cytoskeleton. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Apr 2022]

ITSN1 Products(2)

mRNA	Protein	Name
NM_001136096.3	NP_001129568.1	intersectin-1 isoform a
NM_019227.2	NP_062100.2	intersectin-1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10373452	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of caveolin-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	19258322	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	19258322	RGD
involved in positive regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	16874303	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	19258322	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	19258322	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	19258322	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	19258322	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	12548702	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	19258322	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	19258322	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19258322	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19258322	RGD
located in intracellular vesicle	IDA IDA: Inferred from direct assay	12548702	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12548702	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	19258322	RGD
is active in postsynaptic endocytic zone	IDA IDA: Inferred from direct assay	35072626	RGD
is active in postsynaptic endocytic zone	IMP IMP: Inferred from mutant phenotype	35072626	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intersectin-1

EH domain and SH3 domain regulator of endocytosis 1	intersectin 1 (SH3 domain protein 1A)
intersectin 1 (SH3 domain protein)	intersectin-1-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06997	ITSN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ITSN1	NCBI	NCBI:6453

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