Egln2 - egl-9 family hypoxia-inducible factor 2 Gene

Also Known as PHD1; HPH-1; HPH-3; PHD-1; HIF-PH1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308457

Summary

Enables peptidyl-proline 4-dioxygenase activity. Involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Egln2 Products (1)

mRNA Protein Name
NM_001004083.1 NP_001004083.1 prolyl hydroxylase EGLN2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peptidyl-proline 4-dioxygenase activity IDA
IDA: Inferred from direct assay
15925519 RGD
Biological Process GO Annotation Evidence References Source
involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
IDA: Inferred from direct assay
15925519 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl hydroxylase EGLN2

  • HIF-1alpha prolyl-4-hydroxylase-1

  • HIF-prolyl hydroxylase 1

  • hypoxia-inducible factor prolyl hydroxylase 1

  • prolyl hydroxylase domain-containing protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04213 EGLN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Egln2 NCBI NCBI:112398