Rapgef2 - Rap guanine nucleotide exchange factor 2 Gene

Also Known as PDZ-GEF1; RA-GEF-1; nRap GEP

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 310533

Summary

Enables protein kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of GTPase activity. Located in several cellular components, including neuron projection; neuronal cell body; and synapse. Part of protein-containing complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef2 Products (1)

mRNA	Protein	Name
NM_001107684.1	NP_001101154.1	rap guanine nucleotide exchange factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10548487	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21382555	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in brain-derived neurotrophic factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	17724123	RGD
involved in nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	17724123	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	21382555	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	21382555	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in neuron projection	IDA IDA: Inferred from direct assay	10801446	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10548487	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12391161	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17724123	RGD
located in synapse	IDA IDA: Inferred from direct assay	10548487	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
rap guanine nucleotide exchange factor 2	CNrasGEF PDZ domain-containing guanine nucleotide exchange factor 1 Rap guanine nucleotide exchange factor (GEF) 2 cyclic nucleotide ras GEF neural RAP guanine nucleotide exchange protein rap guanine nucleotide exchange factor 6-like ras/Rap1-associ

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11661	RAPGEF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rapgef2	NCBI	NCBI:9693