Spef2 - sperm flagellar 2 Gene

Also Known as C230086A09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 320277

Summary

Acts upstream of or within several processes, including animal organ morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and sperm axoneme assembly. Located in Golgi apparatus; manchette; and sperm midpiece. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2). [provided by Alliance of Genome Resources, Apr 2022]

Spef2 Products (3)

mRNA Protein Name
NM_001305042.1 NP_001291971.1 sperm flagellar protein 2 isoform 1
NM_001305044.1 NP_001291973.1 sperm flagellar protein 2 isoform 3
NM_177123.4 NP_796097.2 sperm flagellar protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19889948 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain morphogenesis IMP
IMP: Inferred from mutant phenotype
21715716 MGI
acts upstream of or within cerebrospinal fluid circulation IGI
IGI: Inferred from genetic interaction
32704025 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
21715716 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
32704025 MGI
acts upstream of or within mucociliary clearance IGI
IGI: Inferred from genetic interaction
32704025 MGI
acts upstream of or within mucociliary clearance IMP
IMP: Inferred from mutant phenotype
24360193 MGI
acts upstream of or within respiratory system development IMP
IMP: Inferred from mutant phenotype
21715716 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
21715716 MGI
acts upstream of or within sperm axoneme assembly IMP
IMP: Inferred from mutant phenotype
21715716 MGI
acts upstream of or within sperm flagellum assembly IGI
IGI: Inferred from genetic interaction
32704025 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
21715716 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19889948 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19889948 MGI
located in manchette IDA
IDA: Inferred from direct assay
19889948 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
19889948 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm flagellar protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13657 SPEF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spef2 NCBI NCBI:79925