Gjd3 - gap junction protein, delta 3 Gene

Mus musculus

Also known as Cxnr; Gjc1; Gja11; cx30.2

Gene ID: 353155 | Gene type: protein coding

About Gjd3

Summary

Enables gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling and ion channel activity. Involved in negative regulation of cell communication by electrical coupling involved in cardiac conduction and regulation of heart contraction. Located in gap junction. Part of connexin complex. Is expressed in heart. Orthologous to human GJD3 (Gap Junction Protein delta 3). [provided by Alliance of Genome Resources, Apr 2022]

Gjd3 Products(1)

mRNA	Protein	Name
NM_178596.3	NP_848711.2	gap junction delta-3 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling	IMP IMP: Inferred from mutant phenotype	22982984	MGI
enables monoatomic ion channel activity	IDA IDA: Inferred from direct assay	15879306	MGI
enables monoatomic ion channel activity	IGI IGI: Inferred from genetic interaction	15879306	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AV node cell to bundle of His cell communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	16571663	MGI
involved in negative regulation of cardiac conduction	IMP IMP: Inferred from mutant phenotype	16571663	MGI
involved in negative regulation of cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	16571663	MGI
involved in negative regulation of heart rate	IMP IMP: Inferred from mutant phenotype	16571663	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of connexin complex	IGI IGI: Inferred from genetic interaction	15879306	MGI
located in gap junction	IDA IDA: Inferred from direct assay	12681499	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gap junction delta-3 protein

connexin 30.2	connexin r
gap junction alpha-11 protein	gap junction chi-1 protein
gap junction membrane channel protein chi 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05456	GJD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gjd3	NCBI	NCBI:125111

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