INSR - insulin receptor Gene

Also Known as HHF5; CD220

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3643

About INSR

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,112,265-7,294,414 (from NCBI)

This gene has 7 transcripts (splice variants), 289 orthologues, 53 paralogues and is associated with 10 phenotypes. Ubiquitous expression in kidney (RPKM 16.5), spleen (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of Insulin or Other ligands to this receptor activates the Insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe Insulin resistance syndromes including type A Insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

INSR Products (4)

mRNA	Protein	Name
XM_011527988.3	XP_011526290.2	insulin receptor isoform X1
NM_001079817.3	NP_001073285.1	insulin receptor isoform Short preproprotein
NM_000208.4	NP_000199.2	insulin receptor isoform Long preproprotein
XM_011527989.4	XP_011526291.2	insulin receptor isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	6849137	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	9092559	GOA
enables PTB domain binding	IPI IPI: Inferred from physical interaction	7559478	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	19406747	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16957736	GOA
enables insulin binding	IDA IDA: Inferred from direct assay	8440175	GOA
enables insulin binding	IPI IPI: Inferred from physical interaction	8452530	GOA
enables insulin receptor activity	IDA IDA: Inferred from direct assay	6849137	GOA
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	7493946	GOA
enables insulin-like growth factor I binding	IPI IPI: Inferred from physical interaction	8452530	GOA
enables insulin-like growth factor II binding	IPI IPI: Inferred from physical interaction	12138094	GOA
enables insulin-like growth factor receptor binding	IDA IDA: Inferred from direct assay	8452530	GOA
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	7537849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7493946	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	16246733	GOA
enables protein kinase activator activity	IMP IMP: Inferred from mutant phenotype	9819385	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	8496180	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	7537849	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19406747	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	1898103	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9092559	GOA
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	7556070	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	8440175	GOA
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	7693131	GOA
involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	7693131	GOA
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	6849137	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8496180	GOA
involved in positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	3518947	GOA
acts upstream of positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17001305	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	20455999	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11500939	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12138094	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17925406	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12138094	GOA
involved in positive regulation of developmental growth	IMP IMP: Inferred from mutant phenotype	7693131	GOA
involved in positive regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	17925406	GOA
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	7693131	GOA
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	11500939	GOA
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	10747347	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	11500939	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	7556070	GOA
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	25401701	GOA
involved in positive regulation of respiratory burst	IDA IDA: Inferred from direct assay	9092559	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	6849137	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	7537849	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12881524	GOA
involved in regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	7693131	GOA
involved in symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	17001305	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	15182363	GOA
part of insulin receptor complex	IDA IDA: Inferred from direct assay	1898103	GOA
part of insulin receptor complex	IMP IMP: Inferred from mutant phenotype	15069075	GOA
located in membrane	IDA IDA: Inferred from direct assay	8452530	GOA
colocalizes with nuclear envelope	IDA IDA: Inferred from direct assay	19406747	GOA
colocalizes with nuclear lumen	IDA IDA: Inferred from direct assay	19406747	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9092559	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSR Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

fn3

Pkinase_Tyr

0
300
600
900
1200
1382 a.a.

Protein Preferred Names	Protein Names
insulin receptor	IR

INSR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INSR	P06213	DUSP18	Homo sapiens	Q8NEJ0	Anti Tag CoIP	28065597
Intra	INSR	P06213	PTPRR	Homo sapiens	Q15256	Anti Tag CoIP	28065597
Intra	INSR	P06213	AGAP2	Homo sapiens	Q99490	Anti Tag CoIP	21720388
Intra	INSR	P06213	PTPN11	Homo sapiens	Q06124	BioID	35384245
Intra	INSR	P06213	SH2B1	Homo sapiens	Q9NRF2	CoIP	9742218
Intra	INSR	P06213	SH2B1	Homo sapiens	Q9NRF2	Y2H	9742218
Intra	INSR	P06213	PTPRK	Homo sapiens	Q15262	Phosphatase Assay	19167335
Intra	INSR	P06213	IGF1R	Homo sapiens	P08069	Affinity Chrom	35384245
Intra	INSR	P06213	IGF1R	Homo sapiens	P08069	BioID	35384245
Intra	INSR	P06213	IGF1R	Homo sapiens	P08069	Anti Tag CoIP	35384245
Intra	INSR	P06213	IRS1	Homo sapiens	P35568	Anti Tag CoIP	16582879
Intra	INSR	P06213	IRS1	Homo sapiens	P35568	Y2H	7935368
Intra	INSR	P06213	INSRR	Homo sapiens	P14616	Affinity Chrom	35384245
Intra	INSR	P06213	INSRR	Homo sapiens	P14616	Anti Tag CoIP	35384245
Intra	INSR	P06213	IGF1	Homo sapiens	P05019	Competition Binding	8452530
Intra	INSR	P06213	PLCG1	Homo sapiens	P19174	CoIP	9593725
Intra	INSR	P06213	PLCG1	Homo sapiens	P19174	CoIP	14568990
Intra	INSR	P06213	PIK3R1	Homo sapiens	P27986	FRET	10500481
Intra	INSR	P06213	PIK3R1	Homo sapiens	P27986	Affinity Chrom	35384245
Intra	INSR	P06213	PIK3R1	Homo sapiens	P27986	BioID	35384245
Intra	INSR	P06213	GRB10	Homo sapiens	Q13322	Protein 3 Hybrid	9506989
Intra	INSR	P06213	GRB10	Homo sapiens	Q13322	Y2H	9506989
Intra	INSR	P06213	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	INSR	P06213	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	CoIP	11579209
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	CoIP	8999839
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	BiFC	17092689
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Phosphatase Assay	17159996
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Phosphatase Assay	15588987
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	BRET	12634852
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Phosphatase Assay	11163213
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Genetic Interference	8702689
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	X-Ray Diffraction	11163213
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Phosphatase Assay	17481567
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Phosphatase Assay	21806020
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	Anti Bait CoIP	14722096
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	BioID	35384245
Intra	INSR	P06213	PTPN1	Homo sapiens	P18031	FRET	14722096
Cross	INSR	P06213	INS	Bos taurus	P01317	Competition Binding	8452530
Cross	INSR	P06213	Irs1	Rattus norvegicus	P35570	Phosphatase Assay	17135270

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INSR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73244	Insulin Receptor/CD220 Protein, Human (Active, sf9, His-GST)	P06213-1/NP_000199.2 (G989-S1382)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73873	Insulin Receptor/CD220 Protein, Human (HEK293, His, solution)	P06213-1 (H28-K956)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77515	Insulin Receptor/CD220 Protein, Human (Biotinylated, HEK293, His)	P06213-1 (H28-K956)	≥ 95%, as determined by reducing SDS-PAGE.

INSR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80192	Insulin Receptor Beta Antibody (YA341)	WB, ICC/IF	Human, Rat
HY-P80193	Insulin Receptor Antibody (YA340)	WB, IHC-P	Human, Mouse
HY-P81795	Insulin Receptor Antibody (YA1540)	WB, ICC/IF	Human, Rat
HY-P83969	Insulin Receptor Antibody (YA3666)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P83969A	Insulin Receptor Antibody (YA3666)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P86076	Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151) Antibody (YA5768)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86186	Insulin Receptor Beta Antibody (YA5878)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypertrichosis
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Myotonic Dystrophy 2	Myotonic Dystrophy Type 2 Proximal Myotonic Myopathy Promm Ricker Syndrome DM2 Dystrophia Myotonica 2 Myotonic Myopathy, Proximal Myotonic Disorders Dystrophia Myotonica Type 2 Proximal Myotonic Dystrophy Ricker Disease Myotonic Dystrophy, Type 2 Dystrophy, Myotonic, Type 2
Hyperinsulinemic Hypoglycemia	Nesidioblastosis Islet Cell Hyperplasia Persistent Hyperinsulinemia Hypoglycemia Of Infancy Hyperinsulinemic Hypoglycaemia
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovarian Disease Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Ovarian Disease	Ovarian Dysfunction Ovarian Diseases Ovarian Disorders Disorder Of Endocrine Ovary
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities	Rabson-Mendenhall Syndrome Mendenhall Syndrome Pineal Hyperplasia And Diabetes Mellitus Syndrome RMS Leprechaunism Insr-Related Severe Syndromic Insulin Resistance Donohue Syndrome
Werner Syndrome	Werner'S Syndrome WRN Adult Progeria Ws Adult Premature Ageing Syndrome Adult Premature Aging Syndrome Werners Syndrome
Donohue Syndrome	Leprechaunism Leprechaunism Syndrome Donohue'S Syndrome LEPRCH
Myotonic Disease	Myotonic Disorders Myotonic Syndrome Symptomatic Myotonia
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Growth Retardation With Sensorineural Deafness And Mental Retardation Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Hyperinsulinism	Hyperinsulinemia
Hyperinsulinemic Hypoglycemia, Familial, 5	Hyperinsulinism Due To Insr Deficiency HHF5 Familial Hyperinsulinemic Hypoglycemia 5 Hyperinsulinemic Hypoglycemia Due To Insr Deficiency Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency Congenital Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Hyperinsulinemic Hypoglycemia Familial 5
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Acanthosis Nigricans	Keratosis Nigricans An
Diabetes Mellitus, Insulin-Resistant, With Acanthosis Nigricans	Insulin-Resistant Diabetes Mellitus And Acanthosis Nigricans Iran, Type A Type A Insulin Resistance Syndrome Insulin Resistance - Type A Insulin-Resistance Syndrome Type A Insulin Receptor, Defect In, With Insulin-Resistant Diabetes Mellitus And Acanthosis Nigricans Diabetes Mellitus, Insulin-Resistant, With Acanthosis Nigricans, Type A Insulin-Resistant Acanthosis Nigricans, Type A Extreme Insulin Resistance With Acanthosis Nigricans, Hirsutism And Abnormal Insulin Receptors Insulin Resistance Syndrome, Type A Type A Insulin Resistance Insulin-Resistant Diabetes Mellitus With Acanthosis Nigricans Type A IRAN TYPE A
Myopathy, Congenital, With Fiber-Type Disproportion	CFTD Fiber-Type Disproportion Myopathy, Congenital Cftdm Myopathy, Congenital, With Fiber-Type Disproportion 1 Congenital Fiber-Type Disproportion Myopathy Myopathy, Congenital, With Fiber Type Disproportion
Fetal Macrosomia
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hyperandrogenism	Hyperandrogenization Syndrome
Disorder Of Sexual Development	Disorder Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Disorders Of Sex Development Sex Differentiation Disorders
Hyperinsulinemic Hypoglycemia, Familial, 4	Hyperinsulinism Due To Glutamodehydrogenase Deficiency HHF4 Familial Hyperinsulinemic Hypoglycemia 4 Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Hyperinsulinism Due To Schad Deficiency Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Congenital Hyperinsulinism Schad Deficiency Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Vagus Nerve Disease	Vagus Nerve Diseases Disorder Of Pneumogastric [10th] Nerve Disorder Of Vagal Nerve Disorder Of Vagus Nerve Vagus Nerve Disorder Disorders Of The Tenth Cranial Nerve Disorders Of 10th Cranial Nerve Disorder Of Pneumogastric Nerve
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Diabetes Mellitus	Diabetes
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Prediabetes Syndrome	Impaired Glucose Tolerance Prediabetes Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Hyperglycemia
Pigmentation Disease	Pigmentation Disorders Skin Pigmentation Disorder
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Insulin-Dependent Diabetes Mellitus Type 1 Diabetes T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.95%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.90%	Yes
HY-15656AR	Ceritinib dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-15656R	Ceritinib (Standard)	Inhibitor	99.72%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990712	Ersodetug	Inhibitor	99.33%	Phase 3

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50866	NVP-AEW541		99.92%	Unkown
HY-13203	NVP-TAE 226		99.77%	Unkown
HY-10252	NVP-ADW742		99.30%	Unkown
HY-15656S	Ceritinib-d7	Inhibitor	98.00%	Unkown
HY-RS06847	Insr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-10252A	cis-NVP-ADW742	Inhibitor	/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-15656B	Ceritinib mesylate	Inhibitor	/	Unkown
HY-169066	INSR agonist 1	Agonist	/	Unkown
HY-180972	PROTAC EML4-ALK Degrader-2	Inhibitor	/	Unkown
HY-183292	SH-1092	Inhibitor	/	Unkown
HY-E70730	INSR Recombinant Human Active Protein Kinase		/	Unkown
HY-RS06846	INSR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06848	Insr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991290	IRAB-B	Antagonist	98.30%	Unkown
HY-P991037	Verenafusp alfa		/	Unkown
HY-P991291	XOMA 129	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INSR	RGD	RGD:2917
Bos taurus	INSR	VGNC	VGNC:30221
Canis familiaris	INSR	VGNC	VGNC:42043
Felis catus	INSR	VGNC	VGNC:67811
Mus musculus	INSR	MGD	MGI:96575
Others	INSR	NCBI