2. Gene
  3. DUSP18 - dual specificity phosphatase 18 Gene

DUSP18 - dual specificity phosphatase 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DSP18; DUSP20; LMWDSP20

Gene ID: 150290 | Gene type: protein coding

About DUSP18

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,652,051-30,667,875 (from NCBI)

This gene has 10 transcripts (splice variants), 72 orthologues and 30 paralogues. Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP18 Products(4)

mRNA Protein Name
NM_001304794.2 NP_001291723.1 dual specificity protein phosphatase 18 isoform a
NM_001304795.2 NP_001291724.1 dual specificity protein phosphatase 18 isoform a
NM_001304796.2 NP_001291725.1 dual specificity protein phosphatase 18 isoform b
NM_152511.5 NP_689724.3 dual specificity protein phosphatase 18 isoform a

DUSP18 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (27 - 156)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 18

low molecular weight dual specificity phosphatase 20

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04058 DUSP18 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DUSP18 MGD MGI:1922469
Canis familiaris DUSP18 VGNC VGNC:52930
Bos taurus DUSP18 VGNC VGNC:50047
Rattus norvegicus DUSP18 RGD RGD:1306929
Macaca mulatta DUSP18 VGNC VGNC:71858