DUSP18 - dual specificity phosphatase 18 Gene

Also Known as DSP18; DUSP20; LMWDSP20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 150290

About DUSP18

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,652,051-30,667,875 (from NCBI)

This gene has 10 transcripts (splice variants), 72 orthologues and 30 paralogues. Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues.

Summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine Phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase Phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP18 Products (4)

mRNA Protein Name
NM_001304794.2 NP_001291723.1 dual specificity protein phosphatase 18 isoform a
NM_001304795.2 NP_001291724.1 dual specificity protein phosphatase 18 isoform a
NM_001304796.2 NP_001291725.1 dual specificity protein phosphatase 18 isoform b
NM_152511.5 NP_689724.3 dual specificity protein phosphatase 18 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase activity IDA
IDA: Inferred from direct assay
24531476 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28065597 GOA
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
12408986 GOA
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12591617 GOA
Biological Process GO Annotation Evidence References Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
24531476 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: Inferred from direct assay
12591617 GOA
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
12408986 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12408986 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12408986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP18 Protein Structure

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (27 - 156)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

dual specificity protein phosphatase 18

  • low molecular weight dual specificity phosphatase 20

DUSP18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DUSP18 Q8NEJ0 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
DUSP18 Q8NEJ0 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
DUSP18 Q8NEJ0 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
DUSP18 Q8NEJ0 INSR Homo sapiens P06213
Ub Reconstruction
28065597
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04058 DUSP18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21847 Dusp18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28364 Dusp18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DUSP18 MGD MGI:1922469
Canis familiaris DUSP18 VGNC VGNC:52930
Bos taurus DUSP18 VGNC VGNC:50047
Rattus norvegicus DUSP18 RGD RGD:1306929
Macaca mulatta DUSP18 VGNC VGNC:71858
Others DUSP18 NCBI