Insulin Receptor Antibody (YA340)
(Synonyms: IRR, INSRR, Insulin receptor-related protein, IR-related receptor)Insulin Receptor Antibody (YA340) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Insulin Receptor.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500 | 1:50-1:200 |
Product Details
Insulin Receptor Antibody (YA340) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Insulin Receptor.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 144 kDa
Entrez Gene: 3643 Human ; 16337 Mouse ;
SwissProt: P06213 Human ; P15208 Mouse ; P15127 Rat
OMIM: 262190 Human
Synthetic peptide corresponding to Human Insulin Receptor R.AA range:12-61.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. The insulin receptor exists in two isoforms, IR-A and IR-B, expressed in different relative abundance in the various organs and tissues. The two IR isoforms have similar binding affinity for insulin but different affinity for insulin-like growth factor (IGF) -2 and proinsulin, which are bound by IR-A but not IR-B. The insulin receptor has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Subunit
Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain
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SwissProt ID
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Synonyms
IRR, INSRR, Insulin receptor-related protein, IR-related receptor
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Research Field
Signal Transduction
Documentation
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