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NVP-AEW541 dihydrochloride

(Synonyms: AEW541 dihydrochloride)
13 Cited Publications
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Based on 13 publication(s) in Google Scholar

NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 dihydrochloride also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 dihydrochloride has antitumor activity.

For research use only. We do not sell to patients.

  • CAS No.: 2320261-63-8
  • Formula: C27H31Cl2N5O
  • Molecular Weight:512.47
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • NVP-AEW541 dihydrochloride Chemical Structure
    NVP-AEW541 dihydrochloride Chemical Structure
  • Experimental Validation Results for NVP-AEW541 dihydrochloride
  • Experimental Validation Results for NVP-AEW541 dihydrochloride
  • Experimental Validation Results for NVP-AEW541 dihydrochloride
  • Experimental Validation Results for NVP-AEW541 dihydrochloride
  • Experimental Validation Results for NVP-AEW541 dihydrochloride
  • Experimental Validation Results for NVP-AEW541 dihydrochloride
CAS No.: 2320261-63-8
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  • NVP-AEW541 dihydrochloride Chemical Structure
    NVP-AEW541 dihydrochloride Chemical Structure
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    NVP-AEW541 dihydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2026 Mar 12:e20455. [Abstract]

    Customer Validation
     The percentage of JAr spheroids that adhere to Ishikawa cells treated with DHT (0.5 µM), DHT + IGFBP5 (100 ng/ml), DHT + IGF1 (50 ng/ml), DHT + IGFBP5 + IGF1 and DHT + IGFBP5 + NVP‐AEW541 (10 µM).

  • 1/16

    NVP-AEW541 dihydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 25:148:157378. [Abstract]

    Customer Validation
     The qRT-PCR results showed that IGF-1 mRNA expression was significantly increased in the DEX+H-ECH group, whereas NVP-AEW541 completely reversed this effect.

  • 1/16

    NVP-AEW541 dihydrochloride purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 25:148:157378. [Abstract]

    Customer Validation
     Western blot analysis further confirmed that IGF-1, IGF-1R, PI3K, and AKT protein expression, as well as p-PI3K/p-AKT phosphorylation levels, were significantly upregulated in the DEX+H-ECH group, and this trend was blocked by NVP-AEW541 (10 μM), restoring these indicators to the levels observed in the DEX-only treatment group.

  • 1/16

    NVP-AEW541 dihydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Parkinsons Dis. 2025 Jun 7;11(1):157. [Abstract]

    Customer Validation
     After 24 h transfection with V5-DNAJB1, SH-SY5Y cells were treated with indicated INSR inhibitor (NVP-AEW541: 10 μM) for 2 h. DNAJB1 phosphorylation was detected by the anti-phosphor-Y5-specific antibody. Data was analyzed by unpaired two-tailed Student’s t-test.

  • 1/16

    NVP-AEW541 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Mar 11;44(3):115381. [Abstract]

    Customer Validation
     IGF-1R and Akt phosphorylation status of hrEFPrx1 MSCLC propagated in growth medium supplemented with 10%FCS or serum-starved for 5 hours,followed by treatment with the IGF-1R inhibitor NVP-AEW541 for 2 hours at 1µM (compared to nontreated control).

  • 1/16

    NVP-AEW541 dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Mar 11;44(3):115381. [Abstract]

    Customer Validation
     Determination of IC50 values for NVP-AEW541 on hr-EFPrx1 MSCLCs in both 2D and 3D (spheroid) formats.

  • NVP-AEW541 dihydrochloride