MIR195 - microRNA 195 Gene
Also Known as MIRN195; mir-195; miRNA195
Species: Homo sapiens
About MIR195
This gene has 1 transcript (splice variant), 41 orthologues and 4 paralogues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables lncRNA binding |
IDA
IDA: Inferred from direct assay
|
31921616 | GOA |
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
25240198 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
24294368 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Adrenal Cortical Carcinoma |
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| Hepatocellular Carcinoma |
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| Heart Disease |
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| Squamous Cell Carcinoma, Head And Neck |
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| Pancreatitis, Hereditary |
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| Schizophrenia |
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| Leukemia, Chronic Lymphocytic |
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| Systemic Lupus Erythematosus |
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| Bladder Cancer |
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| Leukemia, Acute Myeloid |
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| Colorectal Cancer |
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| Ovarian Cancer |
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| Lung Cancer |
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| Prostate Cancer |
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| Breast Cancer |
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| Cerebral Atherosclerosis |
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| Bone Sarcoma |
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| Oral Cavity Cancer |
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| Aortic Aneurysm |
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| Aortic Disease |
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| Cervix Disease |
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| Tongue Disease |
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| Verrucous Carcinoma |
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| Aortic Dissection |
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| Cardiovascular Organ Benign Neoplasm |
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| Mild Pre-Eclampsia |
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| Tongue Carcinoma |
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| Tongue Squamous Cell Carcinoma |
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| Uterine Anomalies |
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| Aortic Valve Disease 2 |
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| Colonic Disease |
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| Large Intestine Cancer |
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| Heart Valve Disease |
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| Renal Cell Carcinoma, Nonpapillary |
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| Aortic Valve Disease 1 |
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| Subglottis Benign Neoplasm |
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| Cell Type Benign Neoplasm |
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| Urinary System Disease |
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| Respiratory System Cancer |
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| Gastrointestinal System Cancer |
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| Ovarian Serous Carcinoma |
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| Stomach Disease |
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| Aortic Aneurysm, Familial Abdominal, 1 |
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| Endocrine Gland Cancer |
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| Head And Neck Cancer |
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| Gastrointestinal System Disease |
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| Intestinal Disease |
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| Arteries, Anomalies Of |
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| Nasopharyngeal Carcinoma |
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| Thoracic Cancer |
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| Bladder Disease |
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| Male Reproductive Organ Cancer |
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| Female Reproductive System Disease |
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| Respiratory System Disease |
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| Reproductive System Disease |
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| Myocardial Infarction |
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| Male Reproductive System Disease |
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| Connective Tissue Cancer |
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| Upper Respiratory Tract Disease |
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| Pancreas Disease |
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| Pharynx Cancer |
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| Nasopharyngeal Disease |
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| Prostate Disease |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Endocrine System Disease |
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| Breast Disease |
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| Oral Squamous Cell Carcinoma |
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| Bone Cancer |
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| Psychotic Disorder |
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| Inherited Metabolic Disorder |
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| Mesothelioma, Malignant |
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| Disease Of Mental Health |
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| Lung Cancer Susceptibility 3 |
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| Meningioma, Familial |
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| Connective Tissue Disease |
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| Nervous System Disease |
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| Lipoprotein Quantitative Trait Locus |
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| Alzheimer Disease, Familial, 1 |
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| Dilated Cardiomyopathy |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR195 | RGD | RGD:2325346 |
| Mus musculus | MIR195 | MGD | MGI:2676859 |