MYCL - MYCL proto-oncogene, bHLH transcription factor Gene

Homo sapiens

Also known as LMYC; L-Myc; MYCL1; bHLHe38

Gene ID: 4610 | Gene type: protein coding

About MYCL

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,895,428-39,901,917 (from NCBI)

This gene has 4 transcripts (splice variants), 270 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in skin (RPKM 18.4), pancreas (RPKM 11.3) and 17 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Located in chromosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MYCL Products(3)

mRNA	Protein	Name
NM_001033081.3	NP_001028253.1	protein L-Myc isoform 1
NM_001033082.3	NP_001028254.2	protein L-Myc isoform 3
NM_005376.5	NP_005367.2	protein L-Myc isoform 2

MYCL Protein Structure

Myc_N

HLH

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

protein L-Myc

class E basic helix-loop-helix protein 38

Related Diseases

Diseases

Alias

Apocrine Adenosis Of Breast

Apocrine Adenosis Of The Breast

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Lower Lip Cancer

Small Cell Cancer Of The Lung

Small Cell Lung Cancer	Small Cell Lung Carcinoma
Sclc	Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma	Sclc1
Sccl	Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung	Carcinoma, Small Cell

Cerebral Primitive Neuroectodermal Tumor

Pnet Of Cerebrum

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08883	MYCL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MYCL	VGNC	VGNC:43529
Bos taurus	MYCL	VGNC	VGNC:31787
Felis catus	MYCL	VGNC	VGNC:80286
Rattus norvegicus	MYCL	RGD	RGD:1588591
Macaca mulatta	MYCL	VGNC	VGNC:100016
Mus musculus	MYCL	MGD	MGI:96799