2. Gene
  3. DOT1L - DOT1 like histone lysine methyltransferase Gene

DOT1L - DOT1 like histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Canis lupus familiaris (sub-species: familiaris)
Gene ID: 485073 | Gene type: protein coding

About DOT1L

Primary_assembly 20: 57,536,089-57,601,126 reverse strand.ROS_Cfam_1.0:CM025119.1

This gene has 4 transcripts (splice variants) and 205 orthologues.

DOT1L Products(5)

mRNA Protein Name
XM_038429231.1 XP_038285159.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4
XM_038429228.1 XP_038285156.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
XM_038429230.1 XP_038285158.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
XM_038429229.1 XP_038285157.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2
XM_038429232.1 XP_038285160.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5

DOT1L Protein Structure

DOT1

DOT1: pfam08123 (114 - 316)

CC_DOT1L

CC_DOT1L: cd20902 (482 - 546)

Mplasa_alph_rch

Mplasa_alph_rch: cl37461 (511 - 660)

PHA03307

PHA03307: cl33723 (739 - 1122)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1707 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase, H3 lysine-79 specific

LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-79 specific

DOT1-like, histone H3 methyltransferase

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15227 EPZ004777 Inhibitor 99.74% Unkown
HY-15650 SGC0946 Inhibitor 99.68% Unkown
HY-135127 Dot1L-IN-4 Inhibitor 99.67% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-15227A EPZ004777 hydrochloride Inhibitor 98.92% Unkown
HY-135128 Dot1L-IN-5 Inhibitor 99.82% Unkown
HY-121093 DC-S239 Inhibitor 99.73% Unkown
HY-101520A Dot1L-IN-1 TFA Inhibitor 99.59% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-181789 DOT1L808 Degrader / Unkown
HY-101520 Dot1L-IN-1 Inhibitor / Unkown
HY-168083 Dot1L-IN-9 Inhibitor / Unkown
HY-145813 MU1656 Inhibitor / Unkown
HY-146724 Dot1L-IN-7 Inhibitor / Unkown
HY-181790 DOT1L ligand-2 Ligand / Unkown
HY-115619 EPZ004777 formate Inhibitor / Unkown
HY-15650A SGC0946 TFA Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DOT1L NCBI NCBI:84444