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Cat. No.: HY-146724

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Dot1L-IN-7

Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells.

For research use only. We do not sell to patients.

CAS No.: 2580940-76-5
Formula: C₂₃H₂₇N₉O₂
Molecular Weight:461.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Dot1L-IN-7 Chemical Structure

CAS No.: 2580940-76-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target_[1]

DOT1L

1 μM (IC₅₀)

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Bone marrow cell	IC₅₀	1 μM Compound: 25	Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 11 days by hemocytometry Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 11 days by hemocytometry	[PMID: 31978781]
Bone marrow cell	IC₅₀	4.2 μM Compound: 25	Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 9 days by hemocytometry Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 9 days by hemocytometry	[PMID: 31978781]
Bone marrow cell	IC₅₀	8.8 μM Compound: 25	Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 6 days by hemocytometry Antiproliferative activity against mouse bone marrow cell transformed with MLL-AF9 assessed as reduction in cell growth measured after 6 days by hemocytometry	[PMID: 31978781]

Chemical Information

CAS No. 2580940-76-5
Molecular Weight 461.52
Formula C₂₃H₂₇N₉O₂
SMILES

CC(C)(C1=CC=C(C=C1)NC(C2=NN(C=N2)CC(NCCN3C=CC4=C3N=CN=C4N)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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