2. Gene
  3. DOT1L - DOT1 like histone lysine methyltransferase Gene

DOT1L - DOT1 like histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOT1; KMT4

Gene ID: 84444 | Gene type: protein coding

About DOT1L

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,163,933-2,232,578 (from NCBI)

This gene has 9 transcripts (splice variants) and 205 orthologues. Broad expression in testis (RPKM 18.3), bone marrow (RPKM 5.1) and 22 other tissues.

Summary

The protein encoded by this gene is a Histone Methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant Histone Methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]

DOT1L Products(8)

mRNA Protein Name
NM_032482.3 NP_115871.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform 1
XM_011528361.3 XP_011526663.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X6
NM_001411141.1 NP_001398070.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform 2
XM_047439515.1 XP_047295471.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5
XM_047439513.1 XP_047295469.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
XM_047439514.1 XP_047295470.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4
XM_011528359.3 XP_011526661.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2
XM_005259659.4 XP_005259716.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1

DOT1L Protein Structure

DOT1

DOT1: Histone methylation protein DOT1 (115 - 317)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1537 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase, H3 lysine-79 specific

DOT1 like histone H3K79 methyltransferase

DOT1-like histone methyltransferase

DOT1-like protein

DOT1-like, histone H3 methyltransferase

H3-K79-HMTase

histone H3-K79 methyltransferase

histone methyltransferase DOT1L

lysine N-methyltransferase 4

Recombinant DOT1L Proteins

Cat. No. Product Name Accession Purity
HY-P75283 DOT1L Protein, Human NP_115871 (G2-K416) ≥95%

Related Diseases

Diseases Alias
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15650 SGC0946 Inhibitor 99.68% Unkown
HY-135128 Dot1L-IN-5 Inhibitor 98.57% Unkown
HY-135127 Dot1L-IN-4 Inhibitor 99.60% Unkown
HY-101520A Dot1L-IN-1 TFA Inhibitor 98.56% Unkown
HY-101520 Dot1L-IN-1 Inhibitor / Unkown
HY-145813 MU1656 Inhibitor / Unkown
HY-146724 Dot1L-IN-7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DOT1L VGNC VGNC:61591
Canis familiaris DOT1L VGNC VGNC:54298
Rattus norvegicus DOT1L RGD RGD:1306644
Macaca mulatta DOT1L VGNC VGNC:71901
Mus musculus DOT1L MGD MGI:2143886
Bos taurus DOT1L VGNC VGNC:50607
Others DOT1L NCBI