Ttpa - tocopherol (alpha) transfer protein Gene

Also Known as alpha-TTP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50500

Summary

Enables anion binding activity; lipid transfer activity; and vitamin E binding activity. Involved in several processes, including intermembrane lipid transfer; negative regulation of establishment of blood-brain barrier; and vitamin transport. Acts upstream of or within embryonic placenta development; positive regulation of amyloid-beta clearance; and vitamin E metabolic process. Predicted to be located in cytosol. Predicted to be active in late endosome. Is expressed in liver; placenta; uterus; and yolk sac. Used to study familial isolated deficiency of vitamin E. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Ttpa Products (2)

mRNA Protein Name
NM_001317723.1 NP_001304652.1 alpha-tocopherol transfer protein isoform 2
NM_015767.4 NP_056582.1 alpha-tocopherol transfer protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables lipid transfer activity IDA
IDA: Inferred from direct assay
23599266 MGI
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
23599266 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
23599266 MGI
enables vitamin E binding IDA
IDA: Inferred from direct assay
23599266 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
16014812 MGI
involved in intermembrane lipid transfer IDA
IDA: Inferred from direct assay
23599266 MGI
involved in negative regulation of establishment of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
19923370 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
11076932 MGI
acts upstream of or within positive regulation of amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
26637123 MGI
involved in response to toxic substance IMP
IMP: Inferred from mutant phenotype
19923370 MGI
acts upstream of or within vitamin E metabolic process IMP
IMP: Inferred from mutant phenotype
11076932 MGI
involved in vitamin E metabolic process IMP
IMP: Inferred from mutant phenotype
19923370 MGI
involved in vitamin transport IDA
IDA: Inferred from direct assay
23599266 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-tocopherol transfer protein

  • alpha TTP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15236 TTPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttpa NCBI NCBI:7274