Ttpa - tocopherol (alpha) transfer protein Gene

Mus musculus

Also known as alpha-TTP

Gene ID: 50500 | Gene type: protein coding

About Ttpa

Summary

Enables anion binding activity; lipid transfer activity; and vitamin E binding activity. Involved in several processes, including intermembrane lipid transfer; negative regulation of establishment of blood-brain barrier; and vitamin transport. Acts upstream of or within embryonic placenta development; positive regulation of amyloid-beta clearance; and vitamin E metabolic process. Predicted to be located in cytosol. Predicted to be active in late endosome. Is expressed in liver; placenta; uterus; and yolk sac. Used to study familial isolated deficiency of vitamin E. Human ortholog(s) of this gene implicated in familial isolated deficiency of vitamin E. Orthologous to human TTPA (alpha tocopherol transfer protein). [provided by Alliance of Genome Resources, Apr 2022]

Ttpa Products(2)

mRNA	Protein	Name
NM_001317723.1	NP_001304652.1	alpha-tocopherol transfer protein isoform 2
NM_015767.4	NP_056582.1	alpha-tocopherol transfer protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipid transfer activity	IDA IDA: Inferred from direct assay	23599266	MGI
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	23599266	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	23599266	MGI
enables vitamin E binding	IDA IDA: Inferred from direct assay	23599266	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	16014812	MGI
involved in intermembrane lipid transfer	IDA IDA: Inferred from direct assay	23599266	MGI
involved in negative regulation of establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	19923370	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	11076932	MGI
acts upstream of or within positive regulation of amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	26637123	MGI
involved in response to toxic substance	IMP IMP: Inferred from mutant phenotype	19923370	MGI
acts upstream of or within vitamin E metabolic process	IMP IMP: Inferred from mutant phenotype	11076932	MGI
involved in vitamin E metabolic process	IMP IMP: Inferred from mutant phenotype	19923370	MGI
involved in vitamin transport	IDA IDA: Inferred from direct assay	23599266	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-tocopherol transfer protein

alpha TTP

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15236	TTPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttpa	NCBI	NCBI:7274

Name
Email *

	Sorry, but the email address you supplied was invalid.