2. Gene
  3. Ercc4 - excision repair cross-complementing rodent repair deficiency, complementation group 4 Gene

Ercc4 - excision repair cross-complementing rodent repair deficiency, complementation group 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Xpf

Gene ID: 50505 | Gene type: protein coding

About Ercc4

Summary

Enables TFIID-class transcription factor complex binding activity and promoter-specific chromatin binding activity. Acts upstream of or within DNA repair; UV protection; and regulation of Autophagy. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Is expressed in central nervous system and retina. Used to study xeroderma pigmentosum group F. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; xeroderma pigmentosum; and xeroderma pigmentosum group F. Orthologous to human ERCC4 (ERCC excision repair 4, Endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc4 Products(1)

mRNA Protein Name
NM_015769.2 NP_056584.2 DNA repair endonuclease XPF
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables TFIID-class transcription factor complex binding IDA
IDA: Inferred from direct assay
22323595 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22323595 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
14729965 MGI
acts upstream of or within UV protection IMP
IMP: Inferred from mutant phenotype
14729965 MGI
acts upstream of or within regulation of autophagy IMP
IMP: Inferred from mutant phenotype
18443001 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair endonuclease XPF

DNA excision repair protein ERCC-4

DNA repair endonuclease subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04481 ERCC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc4 NCBI NCBI:2072