2. Gene
  3. DOT1L - DOT1 like histone lysine methyltransferase Gene

DOT1L - DOT1 like histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Bos taurus
Gene ID: 510442 | Gene type: protein coding

About DOT1L

Primary_assembly 7: 21,334,365-21,386,441 forward strand.ARS-UCD1.2:CM008174.2

This gene has 2 transcripts (splice variants) and 205 orthologues.

DOT1L Products(10)

mRNA Protein Name
XM_010807068.3 XP_010805370.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X4
XM_010807071.3 XP_010805373.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X5
XM_010807072.3 XP_010805374.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X6
XM_010807066.3 XP_010805368.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
XM_024995042.1 XP_024850810.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X8
XM_005209068.4 XP_005209125.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
XM_024995041.1 XP_024850809.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3
XM_010807067.3 XP_010805369.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2
XM_010807073.3 XP_010805375.1 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X9
XM_003586273.5 XP_003586321.2 histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X7

DOT1L Protein Structure

DOT1

DOT1: pfam08123 (114 - 316)

PTZ00449

PTZ00449: cl33186 (298 - 481)

CC_DOT1L

CC_DOT1L: cd20902 (482 - 546)

Mplasa_alph_rch

Mplasa_alph_rch: cl37461 (511 - 660)

PHA03307

PHA03307: cl33723 (776 - 1119)

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  • 1714 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase, H3 lysine-79 specific

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15593 Pinometostat Inhibitor 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15227 EPZ004777 Inhibitor 99.74% Unkown
HY-15650 SGC0946 Inhibitor 99.68% Unkown
HY-135127 Dot1L-IN-4 Inhibitor 99.67% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-15227A EPZ004777 hydrochloride Inhibitor 98.92% Unkown
HY-135128 Dot1L-IN-5 Inhibitor 99.82% Unkown
HY-121093 DC-S239 Inhibitor 99.73% Unkown
HY-101520A Dot1L-IN-1 TFA Inhibitor 99.59% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-181789 DOT1L808 Degrader / Unkown
HY-101520 Dot1L-IN-1 Inhibitor / Unkown
HY-168083 Dot1L-IN-9 Inhibitor / Unkown
HY-145813 MU1656 Inhibitor / Unkown
HY-146724 Dot1L-IN-7 Inhibitor / Unkown
HY-181790 DOT1L ligand-2 Ligand / Unkown
HY-115619 EPZ004777 formate Inhibitor / Unkown
HY-15650A SGC0946 TFA Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens DOT1L NCBI NCBI:84444