DET1 - DET1 partner of COP1 E3 ubiquitin ligase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55070

About DET1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,501,919-88,546,703 (from NCBI)

This gene has 8 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.7) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein Ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DET1 Products (4)

mRNA Protein Name
NM_001144074.3 NP_001137546.1 DET1 homolog isoform 2
NM_001321594.2 NP_001308523.1 DET1 homolog isoform 3
NM_001321596.1 NP_001308525.1 DET1 homolog isoform 2
NM_017996.5 NP_060466.2 DET1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14739464 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
14739464 GOA
enables ubiquitin protein ligase binding IMP
IMP: Inferred from mutant phenotype
14739464 GOA
enables ubiquitin-like ligase-substrate adaptor activity IPI
IPI: Inferred from physical interaction
14739464 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IPI
IPI: Inferred from physical interaction
14739464 GOA
involved in protein ubiquitination IPI
IPI: Inferred from physical interaction
14739464 GOA
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
14739464 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16949367 GOA
part of Cul4A-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14739464 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DET1 Protein Structure

Det1

Det1: De-etiolated protein 1 Det1 (142 - 547)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 550 a.a.
Protein Preferred Names Protein Names

DET1 homolog

  • DET1, COP1 ubiquitin ligase partner

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03706 DET1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DET1 VGNC VGNC:49598
Rattus norvegicus DET1 RGD RGD:1309793
Mus musculus DET1 MGD MGI:1923625
Macaca mulatta DET1 VGNC VGNC:99197
Felis catus DET1 VGNC VGNC:80989
Bos taurus DET1 VGNC VGNC:49548