PCIF1 - phosphorylated CTD interacting factor 1 Gene

Also Known as CAPAM; hCAPAM; hPCIF1; C20orf67; PPP1R121

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63935

About PCIF1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,934,683-45,948,020 (from NCBI)

This gene has 3 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in ovary (RPKM 21.7), thyroid (RPKM 17.5) and 25 other tissues.

Summary

Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PCIF1 Products (1)

mRNA Protein Name
NM_022104.4 NP_071387.1 mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II C-terminal domain binding IDA
IDA: Inferred from direct assay
18294453 GOA
enables RNA polymerase II C-terminal domain phosphoserine binding IDA
IDA: Inferred from direct assay
32814042 GOA
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
30467178 GOA
enables mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IDA
IDA: Inferred from direct assay
30467178 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA processing IDA
IDA: Inferred from direct assay
30467178 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
31279659 GOA
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
30467178 GOA
NOT involved in regulation of translation IDA
IDA: Inferred from direct assay
31279658 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18294453 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCIF1 Protein Structure

WW

WW: WW domain (48 - 75)

PCIF1_WW

PCIF1_WW: Phosphorylated CTD interacting factor 1 WW domain (446 - 621)

  • 0
  • 200
  • 400
  • 600
  • 704 a.a.
Protein Preferred Names Protein Names

mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase

  • PDX-1 C terminus-interacting factor 1

Related Diseases

Diseases Alias
Childhood Supratentorial Ependymoma

  • Paediatric Cerebral Ependymoma

  • Paediatric Supratentorial Ependymoblastoma

  • Paediatric Supratentorial Ependymoma

  • Pediatric Cerebral Ependymoma

  • Pediatric Supratentorial Ependymoblastoma

  • Pediatric Supratentorial Ependymoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10151 PCIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16789 Spop Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCIF1 RGD RGD:1310800
Mus musculus PCIF1 MGD MGI:2443858
Bos taurus PCIF1 VGNC VGNC:32630
Canis familiaris PCIF1 VGNC VGNC:44306
Macaca mulatta PCIF1 VGNC VGNC:75621
Felis catus PCIF1 VGNC VGNC:81142
Others PCIF1 NCBI