2. Gene
  3. Lztr1 - leucine-zipper-like transcriptional regulator, 1 Gene

Lztr1 - leucine-zipper-like transcriptional regulator, 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1200003E21Rik

Gene ID: 66863 | Gene type: protein coding

About Lztr1

Summary

This gene encodes a member of the BR-C, ttk and bab-kelch superfamily that, in humans, localizes to the Golgi network and is associated with the Ras / mitogen-activated protein kinase pathway. Loss-of-function mutations in the human ortholog are associated with glioblastoma multiforme, schwannomatosis, Noonan syndrome, and DiGeorge syndrome. [provided by RefSeq, Sep 2016]

Lztr1 Products(3)

mRNA Protein Name
NM_001331226.1 NP_001318155.1 leucine-zipper-like transcriptional regulator 1 isoform 2
NM_001331227.1 NP_001318156.1 leucine-zipper-like transcriptional regulator 1 isoform 3
NM_025808.4 NP_080084.2 leucine-zipper-like transcriptional regulator 1 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
30442762 MGI
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
30442762 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-zipper-like transcriptional regulator 1

LZTR-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07933 LZTR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W556631 LZTR1-KRAS modulator 1 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lztr1 NCBI NCBI:8216