Mcoln2 - mucolipin 2 Gene

Also Known as TRPML2; 3300002C04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68279

Summary

Enables identical protein binding activity. Acts upstream of or within myeloid leukocyte migration and positive regulation of chemokine production. Located in recycling endosome. Is expressed in cochlea. Orthologous to human MCOLN2 (mucolipin TRP cation channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Mcoln2 Products (2)

mRNA	Protein	Name
NM_001005846.2	NP_001005846.1	mucolipin-2 isoform 2
NM_026656.5	NP_080932.2	mucolipin-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26432893	MGI
enables iron ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18794901	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within macrophage migration	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within neutrophil migration	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within positive regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within positive regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within positive regulation of macrophage inflammatory protein 1 alpha production	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	26432893	MGI
acts upstream of or within regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	26432893	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in recycling endosome	IDA IDA: Inferred from direct assay	26432893	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mucolipin-2	mucolipidin 2 transient receptor potential channel mucolipin 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08245	MCOLN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mcoln2	NCBI	NCBI:255231