Iqsec2 - IQ motif and Sec7 domain ArfGEF 2 Gene

Also Known as RGD1562109

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 685244

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of glutamatergic synaptic transmission and positive regulation of long-term synaptic depression. Predicted to be located in presynaptic active zone cytoplasmic component. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; photoreceptor ribbon synapse; and postsynaptic density. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2). [provided by Alliance of Genome Resources, Apr 2022]

Iqsec2 Products (2)

mRNA Protein Name
NM_001277386.2 NP_001264315.1 IQ motif and SEC7 domain-containing protein 2 isoform 2
NM_001277425.2 NP_001264354.2 IQ motif and SEC7 domain-containing protein 2 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
27009485 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
26884337 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
27009485 RGD
involved in regulation of ARF protein signal transduction IGI
IGI: Inferred from genetic interaction
26884337 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

IQ motif and SEC7 domain-containing protein 2

  • IQ motif and Sec7 domain 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06889 IQSEC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Iqsec2 NCBI NCBI:23096