Prdm8 - PR domain containing 8 Gene

Also Known as PFM5; 4930565F05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 77630

Summary

Enables chromatin binding activity; Histone Methyltransferase activity (H3-K9 specific); and transcription corepressor activity. Acts upstream of or within central nervous system projection neuron axonogenesis; histone H3-K9 methylation; and negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; lung; retina; and testis. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to human PRDM8 (PR/SET domain 8). [provided by Alliance of Genome Resources, Apr 2022]

Prdm8 Products (4)

mRNA Protein Name
NM_001407994.1 NP_001394923.1 PR domain zinc finger protein 8
NM_001407995.1 NP_001394924.1 PR domain zinc finger protein 8
NM_001407996.1 NP_001394925.1 PR domain zinc finger protein 8
NM_029947.3 NP_084223.2 PR domain zinc finger protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
22284184 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
19646955 MGI
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
19646955 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22284184 MGI
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
22284184 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within central nervous system projection neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
22284184 MGI
acts upstream of or within corpus callosum morphogenesis IMP
IMP: Inferred from mutant phenotype
22284184 MGI
acts upstream of or within corticospinal tract morphogenesis IMP
IMP: Inferred from mutant phenotype
22284184 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19646955 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
22284184 MGI
acts upstream of or within neurogenesis IDA
IDA: Inferred from direct assay
19050759 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19646955 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PR domain zinc finger protein 8

  • PR domain-containing protein 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11072 PRDM8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22741 Prdm8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29255 Prdm8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdm8 NCBI NCBI:56978