CPTP - ceramide-1-phosphate transfer protein Gene

Also Known as GLTPD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80772

About CPTP

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,324,802-1,328,896 (from NCBI)

This gene has 3 transcripts (splice variants), 338 orthologues and 5 paralogues. Broad expression in testis (RPKM 11.0), colon (RPKM 8.1) and 25 other tissues.

Summary

Enables ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in several processes, including ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of interleukin-1 beta production. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CPTP Products (1)

mRNA Protein Name
NM_001029885.2 NP_001025056.1 ceramide-1-phosphate transfer protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ceramide 1-phosphate binding IDA
IDA: Inferred from direct assay
23863933 GOA
enables ceramide 1-phosphate transfer activity IDA
IDA: Inferred from direct assay
23863933 GOA
enables phospholipid binding IDA
IDA: Inferred from direct assay
23863933 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide 1-phosphate transport IDA
IDA: Inferred from direct assay
23863933 GOA
NOT involved in glycolipid transport IDA
IDA: Inferred from direct assay
23863933 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
29164996 GOA
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
29164996 GOA
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
29164996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPTP Protein Structure

GLTP

GLTP: Glycolipid transfer protein (GLTP) (26 - 177)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

ceramide-1-phosphate transfer protein

  • GLTP domain-containing protein 1

Related Diseases

Diseases Alias
Axenfeld-Rieger Syndrome, Type 1

  • Axenfeld-Rieger Syndrome Type 1

  • RIEG1

  • Rieg

  • Rgs

  • Rieger Syndrome Type 1

  • Rieger Syndrome, Type 1

  • Axenfeld-Rieger Syndrome 1

  • Iridogoniodysgenesis With Somatic Anomalies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03126 CPTP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18129 Cptp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24603 Cptp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CPTP MGD MGI:1933107
Bos taurus CPTP VGNC VGNC:27680
Felis catus CPTP VGNC VGNC:107518
Macaca mulatta CPTP VGNC VGNC:71599
Canis familiaris CPTP VGNC VGNC:39583
Rattus norvegicus CPTP RGD RGD:1359656
Others CPTP NCBI