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GRWD1 - glutamate rich WD repeat containing 1 Gene

Also Known as CDW4; GRWD; RRB1; WDR28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83743

About GRWD1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,445,983-48,457,022 (from NCBI)

This gene has 3 transcripts (splice variants), 180 orthologues and 9 paralogues. Ubiquitous expression in placenta (RPKM 6.8), appendix (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 Ligase. [provided by RefSeq, Feb 2012]

GRWD1 Products (1)

mRNA	Protein	Name
NM_031485.4	NP_113673.3	glutamate-rich WD repeat-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA replication origin binding	IDA IDA: Inferred from direct assay	25990725	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	25990725	GOA
enables histone binding	IDA IDA: Inferred from direct assay	25990725	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17041588	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	25990725	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	25990725	GOA
involved in nucleosome assembly	IMP IMP: Inferred from mutant phenotype	27552915	GOA
involved in nucleosome disassembly	IMP IMP: Inferred from mutant phenotype	27552915	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	25990725	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRWD1 Protein Structure

CAF1C_H4-bd

WD40

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
glutamate-rich WD repeat-containing protein 1	CUL4- and DDB1-associated WDR protein 4

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05850	GRWD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GRWD1	VGNC	VGNC:73213
Bos taurus	GRWD1	VGNC	VGNC:29669
Canis familiaris	GRWD1	VGNC	VGNC:41521
Rattus norvegicus	GRWD1	RGD	RGD:1310649
Felis catus	GRWD1	VGNC	VGNC:62722
Mus musculus	GRWD1	MGD	MGI:2141989
Others	GRWD1	NCBI