ARID5B - AT-rich interaction domain 5B Gene

Also Known as MRF2; DESRT; MRF-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84159

About ARID5B

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:61,901,699-62,096,944 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 21.6), fat (RPKM 15.6) and 24 other tissues.

Summary

This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

ARID5B Products (2)

mRNA Protein Name
NM_001244638.2 NP_001231567.1 AT-rich interactive domain-containing protein 5B isoform 2
NM_032199.3 NP_115575.1 AT-rich interactive domain-containing protein 5B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10329386 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21532585 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
21532585 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
21532585 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8649988 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
21532585 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARID5B Protein Structure

ARID

ARID: ARID/BRIGHT DNA binding domain (319 - 406)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1188 a.a.
Protein Preferred Names Protein Names

AT-rich interactive domain-containing protein 5B

  • ARID domain-containing protein 5B

Related Diseases

Diseases Alias
Adenoid Cystic Carcinoma

  • Adenocystic Carcinoma

  • Cribriform Carcinoma

  • Cylindroma

  • Carcinoma Adenoid Cystic

  • Carcinoma, Adenoid Cystic

  • Adenoid Cystic Carcinoma Of Salivary Gland

  • Eccrine Dermal Cylindroma

  • Carcinoma, Cribriform
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1

  • B-All With Etv6-Runx1

  • B-Lymphoblastic Leukemia/Lymphoma With T(12

  • 21)(P13.2

  • Q22.1)

  • Etv6-Runx1

  • B Lymphoblastic Leukemia/Lymphoma With T(12

  • 21)(P13.2

  • Q22.1)

  • Etv6-Runx1
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Female Reproductive Endometrioid Cancer

  • Endometrioid Tumor

  • Endometrioid Neoplasm

  • Female Reproductive Endometrioid Neoplasm
Childhood Leukemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00974 ARID5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARID5B VGNC VGNC:38101
Macaca mulatta ARID5B VGNC VGNC:69854
Mus musculus ARID5B MGD MGI:2175912
Rattus norvegicus ARID5B RGD RGD:1311735
Bos taurus ARID5B VGNC VGNC:26132
Others ARID5B NCBI