ZMYND15 - zinc finger MYND-type containing 15 Gene

Also Known as SPGF14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84225

About ZMYND15

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,739,833-4,746,119 (from NCBI)

This gene has 6 transcripts (splice variants), 138 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 15.6), lung (RPKM 3.5) and 10 other tissues.

Summary

This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase Enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

ZMYND15 Products (3)

mRNA	Protein	Name
NM_001136046.3	NP_001129518.1	zinc finger MYND domain-containing protein 15 isoform 1
NM_001267822.1	NP_001254751.1	zinc finger MYND domain-containing protein 15 isoform 3
NM_032265.2	NP_115641.1	zinc finger MYND domain-containing protein 15 isoform 2

ZMYND15 Protein Structure

zf-MYND

0
200
400
600
742 a.a.

Protein Preferred Names	Protein Names
zinc finger MYND domain-containing protein 15

Related Diseases

Diseases	Alias
Spermatogenic Failure 14	SPGF14
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spermatogenic Failure 15	SPGF15 Spermatogenic Failure, 15
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia
Infertility
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16095	ZMYND15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16693	Cxcl16 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZMYND15	VGNC	VGNC:67265
Bos taurus	ZMYND15	VGNC	VGNC:37204
Mus musculus	ZMYND15	MGD	MGI:3603821
Canis familiaris	ZMYND15	VGNC	VGNC:48653
Macaca mulatta	ZMYND15	VGNC	VGNC:79299
Rattus norvegicus	ZMYND15	RGD	RGD:1309845