AOPEP - aminopeptidase O (putative) Gene

Also Known as APO; AP-O; DYT31; ONPEP; C90RF3; C9orf3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84909

About AOPEP

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:94,726,699-95,150,224 (from NCBI)

This gene has 21 transcripts (splice variants), 227 orthologues, 11 paralogues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 4.6), endometrium (RPKM 4.2) and 24 other tissues.

Summary

This gene encodes a member of the M1 zinc Aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

AOPEP Products (17)

mRNA Protein Name
NM_001193329.3 NP_001180258.1 aminopeptidase O isoform 1
NM_001193331.3 NP_001180260.1 aminopeptidase O isoform 4
NM_001386061.1 NP_001372990.1 aminopeptidase O isoform 5
NM_001386062.2 NP_001372991.1 aminopeptidase O isoform 6
NM_001386063.2 NP_001372992.1 aminopeptidase O isoform 7
NM_001386066.1 NP_001372995.1 aminopeptidase O isoform 3
NM_001386067.1 NP_001372996.1 aminopeptidase O isoform 8
NM_001386068.1 NP_001372997.1 aminopeptidase O isoform 3
NM_001386069.1 NP_001372998.1 aminopeptidase O isoform 9
NM_001386070.1 NP_001372999.1 aminopeptidase O isoform 10
NM_001386071.1 NP_001373000.1 aminopeptidase O isoform 4
NM_001386072.1 NP_001373001.1 aminopeptidase O isoform 11
NM_001386073.1 NP_001373002.1 aminopeptidase O isoform 12
NM_001386074.1 NP_001373003.1 aminopeptidase O isoform 13
NM_001386075.1 NP_001373004.1 aminopeptidase O isoform 2
NM_001386076.1 NP_001373005.1 aminopeptidase O isoform 14
NM_032823.6 NP_116212.3 aminopeptidase O isoform 2

AOPEP Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (244 - 353)

Peptidase_MA_2

Peptidase_MA_2: Peptidase MA superfamily (477 - 611)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: Leukotriene A4 hydrolase, C-terminal (673 - 818)

  • 0
  • 200
  • 400
  • 600
  • 819 a.a.
Protein Preferred Names Protein Names

aminopeptidase O

Related Diseases

Diseases Alias
Dystonia 31

  • DYT31

  • Zech-Boesch Syndrome
Tracheoesophageal Fistula With Or Without Esophageal Atresia

  • Esophageal Atresia With Or Without Tracheoesophageal Fistula

  • Esophageal Atresia
Fanconi Anemia, Complementation Group C

  • Fanconi Anemia Complementation Group C

  • FANCC

  • Facc

  • Fac

  • Fa3

  • Fanconi Pancytopenia Type 3

  • Fanconi Pancytopenia, Type 3

  • Faces Syndrome

  • Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

  • Friedman-Goodman Syndrome

  • Abnormality Of The Face
Inherited Cancer-Predisposing Syndrome

  • Hereditary Cancer-Predisposing Syndrome
Bap1 Tumor Predisposition Syndrome

  • Bap1-Related Tumor Predisposition Syndrome

  • Common Syndrome

  • Bap1 Cancer Syndrome

  • Bap1-Tpds

  • Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms

  • Tumor Predisposition Syndrome

  • Tumor Susceptibility Linked To Germline Bap1 Mutations

  • Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms

  • Tumor Predisposition
Esophageal Atresia

  • Tracheoesophageal Fistula

  • Congenital Atresia Of Esophagus

  • Congenital Imperforate Esophagus

  • Imperforate Esophagus

  • Oesophageal Atresia

  • Te Fistula

  • Tef

  • Tracheoesophageal Fistula With Or Without Esophageal Atresia
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00774 AOPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus AOPEP VGNC VGNC:102899
Mus musculus AOPEP MGD MGI:1919311
Rattus norvegicus AOPEP RGD RGD:1309592
Macaca mulatta AOPEP VGNC VGNC:103243